G-protein-coupled receptor
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In biology, G-protein-coupled receptors are the "largest family of cell surface receptors involved in signal transduction. They share a common structure and signal through heterotrimeric g-proteins."[1]
Two principal signal transduction pathways involving the G-protein coupled receptors are proposed: they use either the cyclic AMP or the phosphatidylinositol diphosphate-inositol triphosphate second messenger systems.[2]
Examples of G-protein-coupled receptors include adrenergic receptors, angiotensin receptors, bradykinin receptors, CCR5 receptor (used by HIV to infect cells), and opioid receptors.
References
- ↑ Anonymous (2024), G-protein-coupled receptor (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Gilman AG (1987). "G proteins: transducers of receptor-generated signals". Annu. Rev. Biochem. 56: 615–49. DOI:10.1146/annurev.bi.56.070187.003151. PMID 3113327. Research Blogging.