G-protein-coupled receptor: Difference between revisions
Jump to navigation
Jump to search
imported>Robert Badgett No edit summary |
imported>Robert Badgett No edit summary |
||
| Line 2: | Line 2: | ||
In [[biology]], '''G-protein-coupled receptors''' are the "largest family of [[cell surface receptor]]s involved in [[signal transduction]]. They share a common structure and signal through [[heterotrimeric g-proteins]]."<ref>{{MeSH}}</ref> | In [[biology]], '''G-protein-coupled receptors''' are the "largest family of [[cell surface receptor]]s involved in [[signal transduction]]. They share a common structure and signal through [[heterotrimeric g-proteins]]."<ref>{{MeSH}}</ref> | ||
Two principal [[signal transduction]] pathways involving the G-protein coupled receptors are proposed: the [[cyclic AMP]] | Two principal [[signal transduction]] pathways involving the G-protein coupled receptors are proposed: they use either the [[cyclic AMP]] or the phosphatidylinositol diphosphate-inositol triphosphate [[second messenger system]]s.<ref name="pmid3113327">{{cite journal |author=Gilman AG |title=G proteins: transducers of receptor-generated signals |journal=Annu. Rev. Biochem. |volume=56 |issue= |pages=615–49 |year=1987 |pmid=3113327 |doi=10.1146/annurev.bi.56.070187.003151 |url=http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.bi.56.070187.003151?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dncbi.nlm.nih.gov |issn=}}</ref> | ||
Examples of G-protein-coupled receptors include [[adrenergic receptor]]s, [[angiotensin receptor]]s, [[bradykinin receptor]]s, [[CCR5 receptor]] (used by [[HIV]] to infect cells), and [[opioid receptor]]s. | Examples of G-protein-coupled receptors include [[adrenergic receptor]]s, [[angiotensin receptor]]s, [[bradykinin receptor]]s, [[CCR5 receptor]] (used by [[HIV]] to infect cells), and [[opioid receptor]]s. | ||
Revision as of 09:14, 9 July 2009
In biology, G-protein-coupled receptors are the "largest family of cell surface receptors involved in signal transduction. They share a common structure and signal through heterotrimeric g-proteins."[1]
Two principal signal transduction pathways involving the G-protein coupled receptors are proposed: they use either the cyclic AMP or the phosphatidylinositol diphosphate-inositol triphosphate second messenger systems.[2]
Examples of G-protein-coupled receptors include adrenergic receptors, angiotensin receptors, bradykinin receptors, CCR5 receptor (used by HIV to infect cells), and opioid receptors.
References
- ↑ Anonymous (2024), G-protein-coupled receptor (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Gilman AG (1987). "G proteins: transducers of receptor-generated signals". Annu. Rev. Biochem. 56: 615–49. DOI:10.1146/annurev.bi.56.070187.003151. PMID 3113327. Research Blogging.