Cyclic AMP: Difference between revisions
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In [[biochemistry]], '''cyclic AMP''' is an "adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a [[Second messenger system|second messenger]] and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including [[epinephrine]], [[glucagon]], and [[ACTH]]."<ref>{{MeSH}}</ref> | In [[biochemistry]], '''cyclic AMP''' is an "adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a [[Second messenger system|second messenger]] and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including [[epinephrine]], [[glucagon]], and [[ACTH]]."<ref>{{MeSH}}</ref> | ||
In [[signal transduction]], [[second messenger system]]s such as adenyl cyclase-cyclic AMP and [[cyclic GMP]] may activate [[protein kinase]]s which then affect downstream targets. | In [[signal transduction]], [[cell surface receptor]]s may activate [[second messenger system]]s such as adenyl cyclase-cyclic AMP and [[cyclic GMP]] which then may activate [[protein kinase]]s which then affect downstream targets. | ||
==Metabolism== | ==Metabolism== | ||
Revision as of 09:33, 9 July 2009
In biochemistry, cyclic AMP is an "adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH."[1]
In signal transduction, cell surface receptors may activate second messenger systems such as adenyl cyclase-cyclic AMP and cyclic GMP which then may activate protein kinases which then affect downstream targets.
Metabolism
Cyclic AMP, along with pyrophasphate, are formed by action of the enzyme adenylate cyclase on adenosine triphosphate (ATP).
Pharmacology
The medication adenosine inhibits the effects intracellular cyclic AMP thus reducing sympathetic stimulation.[2]
References
- ↑ Anonymous (2024), Cyclic AMP (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Keith Parker; Laurence Brunton; Goodman, Louis Sanford; Lazo, John S.; Gilman, Alfred (2006). “Chapter 34. Antiarrhythmic Drugs”, Goodman & Gilman's the pharmacological basis of therapeutics, 11th. New York: McGraw-Hill. ISBN 0-07-142280-3.