Hypertriglyceridemia
In medicine hypertriglyceridemia is a dyslipidemia and is "a condition of elevated levels of triglycerides in the blood".[1]
One cause is hypoalphalipoproteinemia.
Treatment
Clinical practice guidelines state:[2] "Patients in whom triglycerides >500 mg/dL should receive strict diet therapy including avoidance of alcohol, restriction of dietary fat, and avoidance of concentrated carbohydrates (sweets). For triglycerides >1000 mg/dL a very low fat diet should be instituted quickly to reduce chylomicronemia and risk of acute pancreatitis"
Regarding treating triglycerides among patients with diabetes mellitus with levels less than 650 mg/dl, "the combination of fenofibrate and simvastatin did not reduce the rate of fatal cardiovascular events, nonfatal myocardial infarction, or nonfatal stroke, as compared with simvastatin alone" according to a randomized controlled trial. [3] However, among the diabetics with triglycerdies about 204 and HDL less than 34, there was significant better (primary outcome over 5 years reduced from 17% to 12%).[3]
References
- ↑ Anonymous (2024), Hypertriglyceridemia (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ [Management of Dyslipidemia Working Group. VA/DoD clinical practice guideline for the management of dyslipidemia. Washington (DC): Department of Veterans Affairs, Department of Defense; 2006. 140 p.
- ↑ 3.0 3.1 ACCORD Study Group. Ginsberg HN, Elam MB, Lovato LC, Crouse JR, Leiter LA et al. (2010). "Effects of combination lipid therapy in type 2 diabetes mellitus.". N Engl J Med 362 (17): 1563-74. PMID 20228404.