Vasopressin receptor
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Vasopressin receptors are "specific molecular sites or proteins on or in cells to which vasopressins bind or interact in order to modify the function of the cells. Two types of vasopressin receptor exist, the V1 receptor in the vascular smooth muscle and the V2 receptor in the kidneys. The V1 receptor can be subdivided into V1a and V1b (formerly V3) receptors."[1]
Classification
| Type | Second messenger system | Locations | Actions |
|---|---|---|---|
| AVPR1A | phosphatidylinositol/calcium | liver, kidney, peripheral vasculature, brain | vasoconstriction, gluconeogenesis, platelet aggregation, and release of factor VIII and von Willebrand factor; social recognition[2], circadian tau[3] |
| AVPR1B | phosphatidylinositol/calcium | pituitary gland, brain | adrenocorticotropic hormone secretion in response to stress[4]; social interpretation to olfactory cues[5] |
| AVPR2 | adenylate cyclase/cAMP | apical membrane of the cells lining the collecting ducts of the kidneys (especially the cortical and outer medullary collecting ducts) | insertion of aquaporin-2 (AQP2) channels (water channels). This allows water to be reabsorbed down an osmotic gradient, and so the urine is more concentrated. |
References
- ↑ Anonymous (2024), Vasopressin receptor (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Bielsky IF, Hu SB, Szegda KL, Westphal H, Young LJ. Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice.Neuropsychopharmacology. 2004; 29:483-93. PMID 14647484
- ↑ Wersinger SR, Caldwell HK, Martinez L, Gold P, Hu SB, Young WS 3rd. Vasopressin 1a receptor knockout mice have a subtle olfactory deficit but normal aggression. Genes Brain Behav. 2006 Nov 3; [Epub ahead of print] PMID 17083331
- ↑ Lolait SJ, Stewart LQ, Jessop DS, Young WS 3rd, O'Carroll AM. The hypothalamic-pituitary-adrenal axis response to stress in mice lacking functional vasopressin V1b receptors. Endocrinology. 2007;148:849-56. PMID 17122081
- ↑ Wersinger SR, Kelliher KR, Zufall F, Lolait SJ, O'Carroll AM, Young WS 3rd. Social motivation is reduced in vasopressin 1b receptor null mice despite normal performance in an olfactory discrimination task. Horm Behav. 2004;46:638-45. PMID 15555506