Erythrocyte transfusion
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In medicine, erythrocyte transfusion or red blood cell transfusion is the "transfer of erythrocytes from a donor to a recipient or reinfusion to the donor."[1]
Adverse effects
Immunologic reactions
- Febrile nonhemolytic transfusion reactions (FNHTR) due to destruction of incompatible donor white blood cells
- Hemolytic reactions due to blood group incompatibility is "mismatch between donor and recipient blood. Antibodies present in the recipient's serum are directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed."[2]
- Acute hemolytic transfusion reactions due to ABO incompatibility
- Delayed hemolytic transfusion reactions
- Allergic reactions
- Anaphylactic transfusion reactions may occur, especially in patients with IgA-deficiency.
- Urticaria may occur due to the recipient's IgE reacting to antigens from the donor.
- Posttransfusion purpura (PTP) due to thrombocytopenia from platelet antibodies. This is more common in women who have been pregnant.
- Transfusion associated graft-versus-host disease (TA-GVHD)
Chemical reactions
- Hemosiderosis
- Hypocalcemia from citrate toxicity
- Hyperkalemia
- Metabolic alkalosis and hypokalemia due to citrate
Transmission of infection
Other reactions
- Hypothermia
- Circulatory overload
- Hypotension associated with leukoreduced blood
- Transfusion-related acute lung injury (pulmonary leukoagglutinin reaction) (TRALI)
References
- ↑ Anonymous (2024), Erythrocyte transfusion (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Anonymous (2024), Blood group incompatibility (English). Medical Subject Headings. U.S. National Library of Medicine.