Amprenavir

(CC) Image: David E. Volk
Amprenavir.

Amprenavir, also called AMP, AMV, APV and VX-478, is a protease inhibitor used to treat HIV infection. Protease inhibitors block HIV-1 protease, an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs. Its IUPAC chemical name is [(3S)-oxolan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3- hydroxy-1-phenylbutan-2-yl]carbamate.

Brand Names

• Agenerase®
• Prozei®
• Vertex®

External Links

• Amprenavir - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
• Drug Bank at http://www.drugbank.ca/cgi-bin/getCard.cgi?CARD=DB00701