Borna disease virus

From Citizendium
Revision as of 04:41, 18 April 2009 by imported>Nicholas Lawson
Jump to navigation Jump to search
All unapproved Citizendium articles may contain errors of fact, bias, grammar etc. A version of an article is unapproved unless it is marked as citable with a dedicated green template at the top of the page, as in this version of the 'Biology' article. Citable articles are intended to be of reasonably high quality. The participants in the Citizendium project make no representations about the reliability of Citizendium articles or, generally, their suitability for any purpose.

Attention niels epting.png
Attention niels epting.png
This article is currently being developed as part of an Eduzendium student project in the framework of a course entitled Microbiology 201 at Queens College, CUNY. The course homepage can be found at CZ:Biol 201: General Microbiology.
For the course duration, the article is closed to outside editing. Of course you can always leave comments on the discussion page. The anticipated date of course completion is May 21, 2009. One month after that date at the latest, this notice shall be removed.
Besides, many other Citizendium articles welcome your collaboration!


This article is a stub and thus not approved.
 Main Article
 Discussion
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
 
https://en.citizendium.org/wiki/index.php?title=Borna_disease_virus&printable=yes
This editable Main Article is under development and subject to a disclaimer.
Borna disease virus
Virus classification
Group: Group V ssRNA virus
Family: Bornaviridae
Genus: Bornavirus

Classification:

Description and significance:

A neurotropic, noncytolytic, negative, and single-stranded enveloped RNA virus. It has a wide geographic distribution and host range,[1] including horses, sheep, and humans. In humans, it causes a range of neurological disorders ranging from encephalitis[2] to manic-depressive symptoms. Some studies have demonstrated a therapeutic effect of the antiviral agent amantadine in BDV-infected, depressed patients.

Natural Host:

When was your organism discovered?

How and where was it isolated:

Genome structure:

BDV has a ca. 8.9 kb genome size of encapsulated, non-segmented, single-stranded RNA[1][3] with five open reading frames (ORFs).[4] ORFs I, II, and III correspond to 40-kDa p40, 24-kDa p24, and 14.5-kDa p14.5 BDV proteins, respectively.[3]

BDV replicates and transcribes in the nuclei of its hosts

Interesting features:

How does this organism cause disease?

What makes it biologically interesting?

Its application to Biotechnology... its medical importance... major research findings made with it... what's cool about borna disease virus as an organism:


Current Research:

References:

  1. ↑ 1.0 1.1 Richt, J.A., Pfeuffer, I., Christ, M., Frese, K., Bechter, K., Herzog, S. Borna disease virus infection in animals and humans. Emerging Infectious Diseases, 3(3). 1997: 343-352.
  2. ↑ Bode, L., Ludwig, H. Clinical similarities and close genetic relationship of human and animal Borna disease virus. Archives of Virology Supplement, 13. 1997: 167-82
  3. ↑ 3.0 3.1 de la Torre, J.C. Molecular biology of Borna Disease Virus: Prototype of a new group of animal viruses. Journal of Virology, 68(12). 1994: 7669-75.
  4. ↑ Briese, T., Schneemann, A., Lewis, A., Park, Y., Kim, H., Ludwig, H., and Lipkin, I. Genomic organization of Borna disease virus. Proceedings of the National Academy of Sciences, 91(10). 1994: 4362-66.
Retrieved from "https://citizendium.org/wiki/index.php?title=Borna_disease_virus&oldid=607508"