Thrombotic thrombocytopenic purpura: Difference between revisions
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In [[medicine]] and [[hematology]], '''thrombotic thrombocytopenic purpura''' ('''TTP''') is "an acquired, congenital, or familial disorder caused by [[platelet aggregation]] with [[thrombosis]] in terminal arterioles and capillaries. Clinical features include [[thrombocytopenia]]; [[hemolytic anemia]]; [[azotemia]]; [[fever]]; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as [[renal failure]]."<ref>{{MeSH}}</ref> | In [[medicine]] and [[hematology]], '''thrombotic thrombocytopenic purpura''' ('''TTP''') is "an acquired, congenital, or familial disorder caused by [[platelet aggregation]] with [[thrombosis]] in terminal arterioles and capillaries. Clinical features include [[thrombocytopenia]]; [[hemolytic anemia]]; [[azotemia]]; [[fever]]; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as [[renal failure]]."<ref>{{MeSH}}</ref> | ||
Patients with primary TTP may have low von Willebrand factor-degrading protease (ADAMTS13 protein) | Patients with primary TTP may have low von Willebrand factor-degrading protease (ADAMTS13 protein), an [[ADAM Protein]].<ref name="pmid20032506">{{cite journal| author=Hovinga JA, Vesely SK, Terrell DR, Lämmle B, George JN| title=Survival and relapse in patients with thrombotic thrombocytopenic purpura. | journal=Blood | year= 2010 | volume= 115 | issue= 8 | pages= 1500-11; quiz 1662 | pmid=20032506 | ||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=20032506 | doi=10.1182/blood-2009-09-243790 }} </ref> | | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=20032506 | doi=10.1182/blood-2009-09-243790 }} </ref> This deficiency allows thrombi due to von Willebrand factor (vWF) | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 19:27, 25 September 2013
In medicine and hematology, thrombotic thrombocytopenic purpura (TTP) is "an acquired, congenital, or familial disorder caused by platelet aggregation with thrombosis in terminal arterioles and capillaries. Clinical features include thrombocytopenia; hemolytic anemia; azotemia; fever; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as renal failure."[1]
Patients with primary TTP may have low von Willebrand factor-degrading protease (ADAMTS13 protein), an ADAM Protein.[2] This deficiency allows thrombi due to von Willebrand factor (vWF)
References
- ↑ Anonymous (2025), Thrombotic thrombocytopenic purpura (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Hovinga JA, Vesely SK, Terrell DR, Lämmle B, George JN (2010). "Survival and relapse in patients with thrombotic thrombocytopenic purpura.". Blood 115 (8): 1500-11; quiz 1662. DOI:10.1182/blood-2009-09-243790. PMID 20032506. Research Blogging.