Rifampin: Difference between revisions
imported>Robert Badgett (New page: In medicine, '''rifampin''', also called '''rifampicin''' is "a semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, includi...) |
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In [[medicine]], '''rifampin''', also called '''rifampicin''' is "a semisynthetic [[antibiotic]] produced from [[Streptomyces mediterranei]]. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms"<ref>{{MeSH}}</ref> | In [[medicine]], '''rifampin''', also called '''rifampicin''', is "a semisynthetic [[antibiotic]] produced from [[Streptomyces mediterranei]]. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms"<ref>{{MeSH}}</ref> | ||
Among its uses is the treatment of [[staphylococcus aureus]].<ref name="pmid19438638">{{cite journal| author=Nguyen S, Pasquet A, Legout L, Beltrand E, Dubreuil L, Migaud H et al.| title=Efficacy and tolerance of rifampicin-linezolid compared with rifampicin-cotrimoxazole combinations in prolonged oral therapy for bone and joint infections. | journal=Clin Microbiol Infect | year= 2009 | volume= 15 | issue= 12 | pages= 1163-9 | pmid=19438638 | |||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&email=badgett@uthscdsa.edu&retmode=ref&cmd=prlinks&id=19438638 | doi=10.1111/j.1469-0691.2009.02761.x }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref> For this purpose, rifampicin (10 mg/kg twice daily, maximum 900 mg twice daily), intravenously for the first week and then given orally, combined with cotrimoxazole (sulfamethoxazole 40 mg/kg/day, trimethoprim 8 mg/kg/day). | |||
==External links== | |||
{{CZMed}} | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 19:39, 18 January 2010
In medicine, rifampin, also called rifampicin, is "a semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms"[1]
Among its uses is the treatment of staphylococcus aureus.[2] For this purpose, rifampicin (10 mg/kg twice daily, maximum 900 mg twice daily), intravenously for the first week and then given orally, combined with cotrimoxazole (sulfamethoxazole 40 mg/kg/day, trimethoprim 8 mg/kg/day).
External links
The most up-to-date information about Rifampin and other drugs can be found at the following sites.
- Rifampin - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Rifampin - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Rifampin - Detailed information from DrugBank.
References
- ↑ Anonymous (2024), Rifampin (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Nguyen S, Pasquet A, Legout L, Beltrand E, Dubreuil L, Migaud H et al. (2009). "Efficacy and tolerance of rifampicin-linezolid compared with rifampicin-cotrimoxazole combinations in prolonged oral therapy for bone and joint infections.". Clin Microbiol Infect 15 (12): 1163-9. DOI:10.1111/j.1469-0691.2009.02761.x. PMID 19438638. Research Blogging.