Aromatase: Difference between revisions
Jump to navigation
Jump to search
imported>David E. Volk mNo edit summary |
imported>David E. Volk No edit summary |
||
| Line 1: | Line 1: | ||
{{subpages}} | {{subpages}} | ||
{{Image|Aromatase CytP450 with androstenedione.png|right|250px|Human placental aromatase bound to ligands [[androstenedione]] (cyan) and [[heme]] (yellow). Coordinates obtained by the RCSB Protein Data Bank (3EQM)}} | |||
'''Aromatase''' is an [[enzyme]] that removes the C-19 methyl group and oxidizes the 3- and 17-positions of steroids, including reactions that convert androgenic steroids (testosterone) into estrogenic steroids (estrogen). Because some tumors are estrogen-sensitive, [[aromatase inhibitor]]s are sometimes used to treat cancer, mostly in post-menopausal women because aromatase inhibitors do not block estrogen synthesis in the ovaries. | '''Aromatase''' is an [[enzyme]] that removes the C-19 methyl group and oxidizes the 3- and 17-positions of steroids, including reactions that convert androgenic steroids (testosterone) into estrogenic steroids (estrogen). Because some tumors are estrogen-sensitive, [[aromatase inhibitor]]s are sometimes used to treat cancer, mostly in post-menopausal women because aromatase inhibitors do not block estrogen synthesis in the ovaries. | ||
Revision as of 15:23, 31 May 2009
(CC) Image: David E. Volk
Human placental aromatase bound to ligands androstenedione (cyan) and heme (yellow). Coordinates obtained by the RCSB Protein Data Bank (3EQM)
Human placental aromatase bound to ligands androstenedione (cyan) and heme (yellow). Coordinates obtained by the RCSB Protein Data Bank (3EQM)
Aromatase is an enzyme that removes the C-19 methyl group and oxidizes the 3- and 17-positions of steroids, including reactions that convert androgenic steroids (testosterone) into estrogenic steroids (estrogen). Because some tumors are estrogen-sensitive, aromatase inhibitors are sometimes used to treat cancer, mostly in post-menopausal women because aromatase inhibitors do not block estrogen synthesis in the ovaries.