Apolipoprotein E4: Difference between revisions
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In [[medicine]], '''apolipoprotein E4''' is an [[apolipoprotein]] which is "a major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from apolipoprotein E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for [[Alzheimer's disease|Alzheimer disease]] and [[cardiovascular disease]]s.<ref>{{MeSH}}</ref> | In [[medicine]], '''apolipoprotein E4''' (apolipoprotein ε4) is an [[apolipoprotein]] which is "a major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from apolipoprotein E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for [[Alzheimer's disease|Alzheimer disease]] and [[cardiovascular disease]]s.<ref>{{MeSH}}</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 21:18, 1 September 2010
In medicine, apolipoprotein E4 (apolipoprotein ε4) is an apolipoprotein which is "a major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from apolipoprotein E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for Alzheimer disease and cardiovascular diseases.[1]
References
- ↑ Anonymous (2024), Apolipoprotein E4 (English). Medical Subject Headings. U.S. National Library of Medicine.