Borna disease virus: Difference between revisions
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== What makes it biologically interesting? == | == What makes it biologically interesting? == | ||
Its application to Biotechnology... its medical importance... major research findings made with it... what's cool about borna disease virus as an organism: | Its application to Biotechnology... its medical importance... major research findings made with it... what's cool about borna disease virus as an organism: | ||
Some researchers (i.e. Bode et al, 1997; Dietrich et al, 2000; Dietrich and Bode, 2008; Ohlmeier et al, 2008) have found evidence that amantadine, an antiviral drug, significantly reduces mania and depression in BDV-infected patients with affective disorders. Other studies found no antiviral activity of amantidine on BDV.<ref>Cubitt, B., and de la Torre, J.C. (1997). Amantadine does not have antiviral activity against Borna disease. Archives of Virology, 142(10). 2035-42.</ref><ref>Hallensleben, W., Zocher, M., and Staecheli, P. (1997). Borna disease virus is not sensitive to amantadine. Archives of Virology, 142(10). 2043-8.</ref> | |||
== Current Research: == | == Current Research: == | ||
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Classification:
ICTVdB Virus Code: 01.081.0.01.001. Virus accession number: 81001001. Obsolete virus code: 81.0.1.0.001; superceded accession number: 81010001. NCBI Taxon Identifier NCBI Taxonomy ID: 12455. Type of the genus: 01.081.0.01 Bornavirus; Family: 01.081 Bornaviridae; Order: 01 Mononegavirales.[1]
Viruses: Group V ssRNA viruses; Order: Mononegavirales; Family: Bornaviridae; Genus: Bornavirus
Description and significance:
A nonsegmented, negative, single-stranded, enveloped RNA virus that is spherical in shape with a total size of 80-125nm[2] Its core is 50-60nm in diameter, and its envelope has surface projections approximately 7nm long that evenly cover the surface.[1]
It is neurotropic and noncytolytic and has a wide geographic distribution and host range,[3] including horses, sheep, and humans. In humans, it causes a range of neurological disorders ranging from encephalitis[4] to manic-depressive symptoms. Some studies have demonstrated a therapeutic effect of the antiviral agent amantadine in BDV-infected, depressed patients.
Natural Host:
Domain Eucarya, Kingdom Animalia, Phylum Chordata, Subphylum Vertebrata, Class Mammalia and Aves.
Class Aves, Order Struthioniformes, Family Struthionida (ostrich).
Class Mammalia, Order Scandentia, Family Tupaiidae, Genus Tupaia; Order Primates, Family Hominidae, Genus Homo, Species H. sapiens (human); Order Carnivora, Suborder Fissipedia, Family Felidae, Subfamily Felinae, Genus Felis (cats); Order Perissodactyla, Family Equidae, Genus Equus, Species E. caballus (horse); Order Artiodactyla, Family Bovidae, Subfamily Bovinae, Genus Bos, Species B. taurus (cow); Order Artiodactyla, Family Bovidae, Subfamily Caprinae, Genus Ovis, Species O. aries (sheep); Order Rodentia, Suborder Scurognathi, Family Muridae, Subfamily Murinae, Genus Rattus (rat).[1]
When was your organism discovered?
Borna disease was first discovered in horses in Borna, Saxony, Germany in 1763.[5], but Borna disease virus was only characterized as the causative agent in the early 1900s by Zwick and co-workers in Gieseen, Germany.[3]
How and where was it isolated:
Genome structure:
BDV has a ca. 8.9 kb genome size of encapsulated, non-segmented, single-stranded RNA[3][6] with six open reading frames (ORFs).[7] ORFs I, II, and III correspond to 40-kDa p40, 24-kDa p24, and 14.5-kDa p14.5 BDV proteins, respectively.[6] ORF IV and V are capable of encoding 56-kDa and 180-kDa proteins, respectively, but these have not yet been identified.[6] The five ORFs are flanked by 53 nt of noncoding sequence at the 3' terminus and 91 nt of noncoding sequence at the 5' terminus.[7]
The BDV genome is homologous to Filoviridae, Paramyxoviridae, and Rhabdoviridae in both cistronic and extracistronic regions.[7]
Interesting features:
Unlike other non-segmented negative-strand RNA animal viruses, BDV replicates and transcribes in the nuclei of its hosts.[7] BDV is also unique among known Mononegavirales in that it uses cellular splicing machinery to generate some of its mRNAs.[8]
How does this organism cause disease?
The virus is assumed to be transmitted through nasal, salival, or conjunctival secretions.[3]
It likely gains access to the central nervous system (CNS) via intraaxonal migration through the olfactory nerve or nerve endings in the oropharyngeal and intestinal regions. The virus spreads throughout the CNS by intraaxonal transport and centrifugally into the peripheral nerves.[3]
What makes it biologically interesting?
Its application to Biotechnology... its medical importance... major research findings made with it... what's cool about borna disease virus as an organism:
Some researchers (i.e. Bode et al, 1997; Dietrich et al, 2000; Dietrich and Bode, 2008; Ohlmeier et al, 2008) have found evidence that amantadine, an antiviral drug, significantly reduces mania and depression in BDV-infected patients with affective disorders. Other studies found no antiviral activity of amantidine on BDV.[9][10]
Current Research:
References:
- ↑ 1.0 1.1 1.2 Buchen-Osmond, C. (Ed) (2003). 01.081.0.01.001. Borna disease virus. In: ICTVdB - The Universal Virus Database, version 3. Buchen-Osmond, C. (Ed), ICTVdB Management, Columbia University, New York, USA.
- ↑ Brooks, G.F., Butel, J.S., and Morse, S.A. (2001). Jawetz, Melnick, and Adelberg's Medical Microbiology, 22nd Edition. New York: McGraw-Hill. 320.
- ↑ 3.0 3.1 3.2 3.3 3.4 Richt, J.A., Pfeuffer, I., Christ, M., Frese, K., Bechter, K., Herzog, S. Borna disease virus infection in animals and humans. Emerging Infectious Diseases, 3(3). 1997: 343-352.
- ↑ Bode, L., Ludwig, H. Clinical similarities and close genetic relationship of human and animal Borna disease virus. Archives of Virology Supplement, 13. 1997: 167-82
- ↑ Durrwald, L. (1997). Journal of Veterinary Medicine, 44. 147-184.
- ↑ 6.0 6.1 6.2 de la Torre, J.C. Molecular biology of Borna Disease Virus: Prototype of a new group of animal viruses. Journal of Virology, 68(12). 1994: 7669-75.
- ↑ 7.0 7.1 7.2 7.3 Briese, T., Schneemann, A., Lewis, A., Park, Y., Kim, H., Ludwig, H., and Lipkin, I. Genomic organization of Borna disease virus. Proceedings of the National Academy of Sciences, 91(10). 1994: 4362-66.
- ↑ Hornig, M., Briese, T., and Lipkin, W.I. (2003). Borna disease virus. Journal of NeuroVirology, 9. 259-79.
- ↑ Cubitt, B., and de la Torre, J.C. (1997). Amantadine does not have antiviral activity against Borna disease. Archives of Virology, 142(10). 2035-42.
- ↑ Hallensleben, W., Zocher, M., and Staecheli, P. (1997). Borna disease virus is not sensitive to amantadine. Archives of Virology, 142(10). 2043-8.