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| '''''[[Clostridium difficile]]''''' is a spore-forming, anaerobic, toxin-producing bacterium that is a "common inhabitant of the colon flora in human infants and sometimes in adults. It produces a toxin that causes pseudomembranous enterocolitis in patients receiving antibiotic therapy." ''C. difficile'' superinfection after oral antibiotic therapy, leading to potentially fatal pseudomembranous enterocolitis, has been an increasingly severe public health problem. Indeed, many primary physicians now consider it wise to warn outpatients on antibiotics to seek immediate consultation if they develop severe diarrhea.
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| C. difficile is present at low levels in the gut flora of about 3% of adults. These people however show no symptoms and do not need to be treated. The infection occurs when a person is treated with antibiotics targeted against other bacteria. The disease is for the most part nosocomial. Patients who are hospitalized come in contact and are often inoculated with the bacteria. When the patient is treated with antibiotics, especially those with a broad range of activity, the normal gut flora is disrupted, and C. difficile, with its multi-drug resistance, experiences overgrowth. The bacteria releases large quantities of enterotoxins (toxin A) and cytotoxins (toxin B), causing pseudomembranous enterocolitis.
| | ==Footnotes== |
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| [[Image:img2.gif|thumb|left|250px|scanning electron micrograph of C. difficile]]
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| ====History====
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| In 1935, Hall and O’Toole first isolated the bacteria from the stools of newborns and described it. They named it ''Bacillus difficilis'' because it was hard to isolate and grew very slowly in culture.
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| C. difficile is an important pathogen that is currently increasing in its prevalence world-wide. A complete genome sequence would enable geneticists to come up with a more direct and efficient treatment against the pathogen. The genetic material encodes for antimicrobial resistance, production of toxins (virulence), host interaction (adaptations for survival and growth within the gut environment), and the production of surface structures. The understanding of how these genes interact with their environment will be useful in developing therapies against C. difficile associated diseases.
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| ====Genome Structure==== | |
| Sebaihia et al (2006) determined the complete genomic sequence of ''C. difficile'' strain 630, a highly virulent and multidrug-resistant strain. It was found that the genome consists of a circular chromosome of 4,290,252 bp and a plasmid, pCD630, of 7,881 bp. The chromosome encodes 3,776 predicted coding sequences (CDSs), with resistance, virulence, and host interaction genes, while the plasmid carries only 11 CDSs, none of which has any obvious function. ''C. difficile'' has a highly mobile genome, with 11% of the genome consisting of mobile genetic elements, mostly in the form of conjugative transposons. Conjugative transposons are mobile genetic elements that are capable of integrating into and excising from the host genome and transferring themselves, and are responsible for the evolutionary acquisition by C. difficile of genes involved in resistance, virulence, and host interactions. Some of the mobile elements are prophage sequences. Host interaction genes involve genes that code for metabolic capability adaptations for survival and growth within the gut environment.
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| ''[[Clostridium difficile|.... (read more)]]''
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Latest revision as of 09:19, 11 September 2020
Paramhansa Yogananda circa 1920.
Paramhansa Yogananda (5 Jan 1893–7 Mar 1952) was one of the first Indian teachers from the Hindu spiritual tradition to reside permanently in the West, and in particular, he was the first to teach yoga to Americans. He emphasized the universality of the great religions, and ceaselessly taught that all religions, especially Hinduism and Christianity, were essentially the same in their essence. The primary message of Yogananda was to practice the scientific technique of kriya yoga to be released from all human suffering.
He emigrated from India to the United States in 1920 and eventually founded the Self-Realization Fellowship there in Los Angeles, California. He published his own life story in a book called Autobiography of a Yogi, first published in 1946. In the book, Yogananda provided some details of his personal life, an introduction to yoga, meditation, and philosophy, and accounts of his world travels and encounters with a wide variety of saints and colorful personalities, including Therese Neumann, Mohandas K. Gandhi, Luther Burbank, and Jagadis C. Bose.
Paramhamsa, also spelled Paramahamsa, is a Sanskrit title used for Hindu spiritual teachers who have become enlightened. The title of Paramhansa originates from the legend of the swan. The swan (hansa) is said to have a mythical ability to sip only the milk from a water-and-milk mixture, separating out the more watery part. The spiritual master is likewise said to be able to live in a world like a supreme (param) swan, and only see the divine, instead of all the evil mixed in there too, which the worldly person sees.
Yogananda is considered by his followers and many religious scholars to be a modern avatar.
In 1946, Yogananda published his Autobiography of a Yogi. It has since been translated into 45 languages, and in 1999 was designated one of the "100 Most Important Spiritual Books of the 20th Century" by a panel of spiritual authors convened by Philip Zaleski and HarperCollins publishers.
Awake: The Life of Yogananda is a 2014 documentary about Paramhansa Yogananda, in English with subtitles in seventeen languages. The documentary includes commentary by George Harrison and Ravi Shankar, among others.[1][2]
