Propranolol: Difference between revisions
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==History== | ==History== | ||
Propranolol was developed by Akrimax Pharms. | [[Propranolol]] was developed by James Black who later received the Nobel Prize for this and other work.<ref name="pmid9456487">{{cite journal |author=Stapleton MP |title=Sir James Black and propranolol. The role of the basic sciences in the history of cardiovascular pharmacology |journal=Tex Heart Inst J |volume=24 |issue=4 |pages=336–42 |year=1997 |pmid=9456487 |pmc=325477 |doi= |url= |issn=}}</ref> | ||
Propranolol was marketed in the [[United States of America]] by Akrimax Pharms. Propranolol received approval in the [[United States of America]] November 13, 1967.<ref>[http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.SearchAction&SearchType=BasicSearch&Search_Button=Submit&searchTerm=016418 Drugs@FDA]. U S Food and Drug Administration</ref> | |||
[[Generic drug|Generic]] propranolol was available October 22, 1985.<ref>[http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.SearchAction&SearchType=BasicSearch&Search_Button=Submit&searchTerm=070103 Drugs@FDA]. U S Food and Drug Administration</ref> | [[Generic drug|Generic]] propranolol was available October 22, 1985.<ref>[http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.SearchAction&SearchType=BasicSearch&Search_Button=Submit&searchTerm=070103 Drugs@FDA]. U S Food and Drug Administration</ref> | ||
==Metabolism== | ==Metabolism== | ||
Propranolol is metabolized in the liver by several isoenzymes of [[cytochrome P-450] | Propranolol is metabolized in the liver by several isoenzymes of [[cytochrome P-450]]. | ||
==External links== | ==External links== | ||
Latest revision as of 13:07, 2 February 2023
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| propranolol | |||||||
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| Uses: | hypertention;angina pectoris | ||||||
| Properties: | lipophilic | ||||||
| Hazards: | see side effects & drug interactions | ||||||
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In medicine, propranolol is "a widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for myocardial infarction; arrhythmia; angina pectoris; hypertension; hyperthyroidism; migraine; pheochromocytoma; and anxiety but adverse effects instigate replacement by newer drugs."[1]
History
Propranolol was developed by James Black who later received the Nobel Prize for this and other work.[2]
Propranolol was marketed in the United States of America by Akrimax Pharms. Propranolol received approval in the United States of America November 13, 1967.[3]
Generic propranolol was available October 22, 1985.[4]
Metabolism
Propranolol is metabolized in the liver by several isoenzymes of cytochrome P-450.
External links
The most up-to-date information about Propranolol and other drugs can be found at the following sites.
- Propranolol - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Propranolol - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Propranolol - Detailed information from DrugBank.
References
- ↑ Anonymous (2024), Propranolol (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Stapleton MP (1997). "Sir James Black and propranolol. The role of the basic sciences in the history of cardiovascular pharmacology". Tex Heart Inst J 24 (4): 336–42. PMID 9456487. PMC 325477. [e]
- ↑ Drugs@FDA. U S Food and Drug Administration
- ↑ Drugs@FDA. U S Food and Drug Administration