Randomized controlled trial: Difference between revisions

Latest revision as of 07:36, 31 October 2024

Major developments in randomized controlled trials

International Conference on Harmonization

In 1990, the steering committee was formed for the International Conference on Harmonization.^[3] This led to the recommendations for Good Clinical Practices in the conduct of trials.^[4] Some have considered these guidelines to be burdensome.^[5]

In the United States of America, Good Clinical Practices is overseen by the Food and Drug Administration (http://www.fda.gov/ScienceResearch/SpecialTopics/RunningClinicalTrials/).

Consort Statement

The quality of reporting of the conduct of randomized controlled trials remains problematic.^[6]

In 1996, the Consort Statement was published which improved how trials are reported.^[7] The statement was revised in 2001^[8] and 2010^[9].

As of 2005, among high impact journals, "CONSORT was mentioned in the instructions of 36 (22%) journals (see bmj.com), more often in general and internal medicine journals (8/15; 53%) than in specialty journals (28/152; 18%)".^[10] Changes in 2010 includes reporting of trial registration, availability of the original protocol, and funding. The quality of reporting of trials in psychiatry may be better since introduction of the CONSORT statement.^[11]

Trial registration

In 2004, the International Committee of Medical Journal Editors (ICMJE) announced that all trials starting enrollment after July 1, 2005 must be registered prior to consideration for publication in one of the 12 member journals of the Committee.^[12] However, trial registration may still occur late or not at all.^[13]^[14]

Disclosure of Competing Interests

In 2009, the International Committee of Medical Journal Editors (ICMJE) announced a Uniform Format for Disclosure of Competing Interests in ICMJE Journals.^[15]

Control group

"Control", according to the current Declaration of Helsinki ethical guides, may or may not involve a placebo. If there is no accepted treatment, or the disease is mild and self-limiting, placebo controls may be ethical. If there is accepted treatment, the best accepted treatment becomes the control arm. Trials that are controlled, but not by a placebo, still generate arguments about information value versus ethics.

Placebo controls are important, because the placebo effect can often be strong. The more value a subject believes an unknown drug has, the more placebo effect is has.^[16] The use of historical rather than concurrent controls may lead to exaggerated estimation of effect.^[17]

The placebo effect can be seen in controlled trials of surgical interventions with the control group receiving a sham procedure.^[18]^[19]^[20]

Optimization of the delivery of health care in the control groups is important. This was illustrated in a randomized control trial of extracorporeal membrane oxygenation (ECMO). The ECO showed no improvement in survival although the survival of patients treated with ECMO was similar to prior published results.^[21] In this trial, the authors had protocolized the management of the mechanical ventilation in the control group and found high adherence to the protocols and higher than expected survival in the control group. In a subsequent randomized controlled trial, the authors found that protocolized management mechanical ventilation of was better than usual care management of mechanical ventilation.^[22]

The Hawthorne effect is the improvements seen in control subjects simply from participating in research.^[23]

Blinding

Blinding, where neither participants nor experimenters know what treatment the participants are receiving, is important, especially for trials that have subjective outcomes.^[24] Trials that are not blinded tend to report more favorable results.^[25]^[26]

Variations in design

Cluster-randomized trials

In some settings, health care providers, or healthcare institutions should be randomized rather than randomizing the research subjects.^[27] This should occur when the intervention targets the provider or institutions and thus the results from each subject are not truly independent, but will cluster within the health care provider or healthcare institution. Guidelines exist for conducting cluster randomised trials.^[28] Cluster-randomized trials are not always correctly designed and executed.^[29]

Designing an adequately sized cluster-randomized trial is based on several factors. One factor is the intraclass (intracluster) correlation coefficient (ICC).^[30]^[31] The ICC between clusters is analogous to the variance between subjects in a randomized controlled trial. Just as when randomized controlled trials exhibiting high variance between subjects means a larger study is needed, less correlation between clusters indicates more clusters are needed.

Before-after studies

Uncontrolled before-after studies and controlled before-after studies probably should not be considered variations of a randomized controlled trial, yet if carefully done offer advantages to observational studies.^[32] As in a true cluster-randomized trial, the intervention group can be randomly assigned; however, unlike a cluster-randomized trial, the before-after study does not have enough clusters or groups. An interrupted time series analysis can try to improve plausibility of causation; however, interrupted time series are commonly performed incorrectly.^[33]

Crossover trial

For more information, see: Cross-over study.

In crossover trials, patients start in intervention and controls, but later all patients switch groups.^[34]^[35]

Delayed start trial

In this design, one group is randomized to receive treatment before the control group.^[36] This design allows analysis for disease-modifying effects of treatments. An example of this design was a trial of rasagiline for Parkinson's disease.^[37]

Dose ranging studies

Various study designs exit to determine the optimal dose of a new drug.

Crossover designs have been used.^[38]
Designs that test doses in sequence, such as up and down studies^[39] and adaptive dose-ranging trials^[40], depend upon being able to measure an outcome from the medication that occurs quickly, and the drug's dose can be titrated to achieve the effect.^[41]^[42] An example of this type of outcome is blood pressure.
Parallel designs such as multi-level factorial studies have been used.^[43] Special sample size calculations exist for these designs.^[43]

Factorial design

Factorial randomized controlled trial: number of treatment failures due to severe hallucinations or alcohol withdrawal.^[44]
		Chlordiazepoxide
		Given	Not given
Propranolol	Given	1	4
Propranolol	Not given	0	4
Notes: 1. There were 15 patients in each group.

A factorial design allows two interventions to be studied with ability to measure the treatment effect of each intervention in isolation and in combination.^[45]^[46] Interaction between the two treatments can be displayed with "interaction ratios or odds ratios accompanied by their confidence intervals"^[45] and can be measured with the method of Gail and Simon^[47] or the Breslow-Day test for homogeneity.

Many examples of factorial trials exist.^[48] ^[49]

N of 1 trial

In an "N of 1" trial, also called a "single-subject randomized" trial, a single patient randomly proceeds through multiple blinded crossover comparisons. This address the concerns that traditional randomized controlled trials may not generalize to a specific patient.^[50]

Underlining the difficulty in extrapolating from large trials to individual patients, Sackett proposed the use of N of 1 randomized controlled trials. In these, the patient is both the treatment group and the placebo group, but at different times. Blinding must be done with the collaboration of the pharmacist, and treatment effects must appear and disappear quickly following introduction and cessation of the therapy. This type of trial can be performed for many chronic, stable conditions.^[51] The individualized nature of the single-subject randomized trial, and the fact that it often requires the active participation of the patient (questionnaires, diaries), appeals to the patient and promotes better insight and self-management^[52]^[53] as well as patient safety,^[50] in a cost-effective manner.

Noninferiority and equivalence randomized trials

Noninferiority and equivalency randomized controlled trials.

As stated in The Declaration of Helsinki by the World Medical Association it is unethical to give any patient a placebo treatment if an existing treatment option is known to be beneficial.^[54]^[55] Many scientists and ethicists consider that the U.S. Food and Drug Administration, by demanding placebo-controlled trials, encourages the systematic violation of the Declaration of Helsinki.^[56] In addition, the use of placebo controls remains a convenient way to avoid direct comparisons with a competing drug.

The appropriate use of placebo is being revised.^[57]^[58] When guidelines suggest a placebo is an unethical control, then an "active-control noninferiority trial" may be used.^[59] To establish non-inferiority, the following three conditions should be - but frequently are not - established:^[59]

"The treatment under consideration exhibits therapeutic noninferiority to the active control."
"The treatment would exhibit therapeutic efficacy in a placebo-controlled trial if such a trial were to be performed."
"The treatment offers ancillary advantages in safety, tolerability, cost, or convenience."

Noninferiority and equivalence randomized trial are difficult to execute well.^[59] Guidelines exists for noninferiority and equivalence randomized trials.^[60] In planning the trial, the investigators should choose "a noninferiority or equivalence criterion, and specifying the margin of equivalence with the rationale for its choice."^[60] In reporting the outcomes, the authors should present the confidence intervals to show the reader whether the result was within their noninferiority or equivalence criterion.^[60]

Add-on design

"Sometimes a new agent can be assessed by using an 'add-on' study design in which all patients are given standard therapy and are randomly assigned to also receive either new agent or placebo."^[57]

Pragmatic trials

Consort has described pragmatic trials and standards for their reporting.^[61] CONSORT describes a pragmatic trial as addressing "does the intervention work when used in normal practice" as opposed to an "explanatory trial" that addresses "can the intervention work." CONSORT states that this is not a dichotomy of trial designs, but that pragmatic trials reflect an attitude in the design. CONSORT offers an example of a pragmatic trial^[62] and an explanatory trial.^[63]

The cohort multiple randomized controlled trial may be a practical variation of this design.^[64]

Ethical issues

Background

The Belmont Report was released in 1979 by the National Commission for the Protection of Human Subjects in Biomedical and Behavioral Research.^[65]^[66] The three Belmont principles are beneficence, justice and respect for persons.

The Declaration of Helsinki requires informed consent for participation in a trial. In the United States, there is an approval procedure for clinical trials in human subjects, whether for research only or for potential approval of a commercial drug. Most industrialized countries have such procedures; some permit reciprocal approvals.

In the United States, the Code of Federal Regulations (45 CFR 46.102(d) or http://www.access.gpo.gov/nara/cfr/waisidx_02/45cfr46_02.html) regulates human subjects research. Definition from the Code are:

"Research means a systematic investigation, including research development, testing and evaluation, designed to develop or contribute to generalizable knowledge. Activities which meet this definition constitute research for purposes of this policy, whether or not they are conducted or supported under a program which is considered research for other purposes. For example, some demonstration and service programs may include research activities."
Human subject means a living individual about whom an investigator (whether professional or student) conducting research obtains:
- Data through intervention or interaction with the individual, or
- Identifiable private information.

In the United States, the Code of Federal Regulations defines:

Research that may be exempt from IRB approval (45 CFR 46.101(b))
Research that may be eligible for expedited IRB approval (45 CFR 46.110)
The informed consent process (45 CFR 46.116)

Ethics of randomizing subjects

Determining the justification for experimentation can be difficult.^[67]

The appropriate use of placebo is being revised.^[57]^[58]^[68] One tension is the balance between using placebo to increase scientific rigor versus the unnessessary deprival of active treatment to patients. This is the conundrum faced by Martin Arrowsmith in the book by the same name.^[69]^[70]

Comparing a new intervention to a placebo control may not be ethical when an accepted, effective treatment exists. In this case, the new intervention should be compared to the active control to establish whether the standard of care should change.^[71] The observation that industry sponsored research may be more likely to conduct trials that have positive results suggest that industry is not picking the most appropriate comparison group.^[72] However, it is possible that industry is better at predicting which new innovations are likely to be successful and discontinuing research for less promising interventions before the trial stage.

There are times when placebo control is appropriate even when there is accepted, effective treatment.^[57]^[58]^[68]

There are ethical concerns in comparing a surgical intervention to sham surgery; however, this has been done.^[73]^[20] Guidelines by the American Medical Association address the use of placebo surgery.^[74]

Interim analysis - stopping trials early

Trials are increasingly stopped early^[75]; however, this may induce a bias that exaggerates results^[76]^[75]. Data safety and monitoring boards that are independent of the trial are commissioned to conduct interim analyses and make decisions about stopping trials early.^[77] ^[78]

Reasons to stop a trial early are efficacy, safety, and futility.^[79]^[80]

Regarding efficacy, various rules exist that adjust alpha to decide when to stop a trial early.^[81]^[82]^[83]^[84]^[85] A commonly recommended rules are the O'Brien-Fleming (the O'Brien-Fleming rule requires a varying p-value depending on the number of interim analyses) and the Haybittle-Peto (the Haybittle-Peto which requires p<0.001 to stop a trial early) rule.^[81]^[82]^[86]

Using a more conservative stopping rule reduces the chance of a statistical alpha (Type I) error; however, these rules do not alter that the effect size may be exaggerated.^[87]^[82] According to Bassler, "the more stringent the P-value threshold results must cross to justify stopping the trial, the more likely it is that a trial stopped early will overestimate the treatment effect."^[80] A review of trials stopped early found that the earlier a trial was stopped the larger was its reported treatment effect^[75], especially if the trial had less than 500 total events^[88]. Accordingly, examples exist of trials whose interim analyses were significant, but the trial was continued and the final analysis was less significant or was insignificant.^[89]^[90]^[91]

Methods to correct for exaggeration exists.^[92]^[87] A Bayesian approach to interim analysis may help reduce bias and adjust the estimate of effect.^[93]

As an alternative to the alpha rules, conditional power can help decide when to stop trials early.^[94]^[95]

Unnecessary trials

Some trials may be unnecessary because their hypotheses have already been established.^[96] Using cumulative meta-analysis, 25 of 33 randomized controlled trials of streptokinase for the treatment of acute myocardial infarction were unnecessary.^[97]

Authors of trials may fail to cite prior trials.^[98]

Cumulative meta-analysis prior to a new trial may indicate trials that do not need to be executed.^[99]

Seeding trials

Seeding trials are studies sponsored by industry whose "apparent purpose is to test a hypothesis. The true purpose is to get physicians in the habit of prescribing a new drug."^[100] Examples include the ADVANTAGE^[100] and STEPS^[101] trials.

Measuring outcomes

Subjectively assessed outcomes are more susceptible to bias in trials with inadequate allocation concealment.^[102]

Missing data

Several approaches to handling missing data have been reviewed.^[103]^[104] Regarding assigning an outcome to the patient, using a 'last observation carried forward' (LOCF) analysis may introduce biases.^[105]

Crossover between experimental groups

Regarding group assignment, a 'per protocol' analysis may introduce bias compared to an 'intention to treat' analysis. Intention to treat is not always adequately described.^[106]^[107] This bias may be due to the observations that research subjects who adhere to therapy, whether the therapy be an active treatment or placebo, have a reduction in mortality.^[108]^[109] Thus excluding non-compliant subjects would appear to exaggerate the effects of treatment; however the bias can go both directions.^[110] Analysis options exist.^[111]

Surrogate outcomes

The costs and efforts required to measure primary endpoints such as morbidity and mortality make using surrogate outcomes an option. An example is in the treatment of osteoporosis, the primary outcomes are fractures and mortality whereas the surrogate outcome is changes in bone mineral density.^[112]^[113] Other examples of surrogate outcomes are tumor shrinkage or changes in cholesterol level, blood pressure, HbA1c, CD4 cell count.^[114] Surrogate markers might be acceptable when "the surrogate must be a correlate of the true clinical outcome and fully capture the net effect of treatment on the clinical outcome".^[114] However, surrogate outcomes and their rationale may not be adequately described in trials.^[115]

Composite outcomes

Composite outcomes are problematic if the components of the composite vary in their magnitude and contribution to the composite.^[116]^[117] ^[118] ^[119]

Overdiagnosis

For more information, see: Overdiagnosis.

In trials of mass screening, overdiagnosis is the diagnosis of non-harmful disease. ^[120] Overdiagnosis inflates the importance of the screening problem.

Adverse outcomes

Adverse effects may be discovered only after a trial is concluded, or in the larger populations to which a drug, approved for general release based on trial data, is used. Postmarketing surveillance is intended to detect hazards that the trials are not powerful enough to find.

Analysis

For more information, see: Statistics and Statistical significance.

Dichotomous outcomes may be summarized with relative risk reduction, absolute risk reduction, or the number needed to treat.

Planning analyses prior to conducting the trial

When protocols for trials are publicly accessible, discrepancies between planned and actual analyses may occur.^[121]^[122]

Conflict-of-interests in data analyses

Regarding data analyses of randomized controlled trials, research sponsored by industry may incompletely report or analyze drug toxicity.^[123]^[124] Similarly, industry-sponsored trials may be more likely to omit intention-to-treat analyses.^[125] These problems with statistical analyses have led the Journal of the American Medical Association (JAMA) to require independent analysis of data.^[126]^[127] This policy has been associated with a decreased in the number of trials published by JAMA.^[128]

Subgroup analyses

Subgroup analyses can be misleading due to failure to prespecify hypotheses and to account for multiple comparisons.^[129]^[82]^[130]^[131]

When multiple subgroups are present, examining subgroups with a multivariate risk score may be better than examining subgroups one-variable-at-at-time which may exaggerate the role of subgroups.^[132]

Statistical methods^[133] and criteria^[134] exist for assessing the importance of subgroups. In brief, testing the statistical significance of an interaction (e.g. statistical heterogeneity) between subgroups and a relative measure of outcome. variation in the relative measure.^[134]

The following criteria have been proposed for interpreting the p-value from the test of statistical significance:^[134]

P > 0.1 indicates skepticism of a subgroup effect
P is between 0.1 and 0.01 suggests to "consider the hypothesis"
P less than or equal to 0.001 "take the hypothesis seriously"

Assessing the quality of a trial

Biased trials are more common, sepecially in trials with subjective outcomes, if:^[135]

Inadequate or unclear random-sequence generation
Inadequate or unclear allocation concealment
Lack of or unclear double-blinding

Numerous scales and checklists for assessing quality have been proposed.^[136] A comparison of the Cochrane Collaboration Tool, the Jadad score, and the Schulz approach found that the Cochrane Collaboration Tool required more time to complete, contained some subjective items, and did not well correlate with the Jadad score or Schulz approach.^[137]

Cochrane bias scale

The Cochrane Collaboration uses a six item tool.^[138] Trials that have high or uncertain bias are more likely to report large effect sizes.^[137]

In using the Cochrane tool, if any of the first three items are low quality (randomization, allocation concealment before and during enrollment, blinding), the trial may be considered high or uncertain bias.^[139]

Jadad score

For more information, see: Jadad score.

The Jadad score may be used to assess quality.^[140] The scale focuses on three attributes: randomization, blinding, and dropouts.

Schulz

The Schulz approach assess the quality of allocation concealment.^[141]

Studies of characteristics of trails

Large studies may not be associated with better quality.^[142]

Problems with trials

Small study effect

Small trials report stronger effect estimates.^[143]

Publication bias=

For more information, see: Publication bias.

Publication bias refers to the tendency that trials that show a positive significant effect are more likely to be published than those that show no effect or are inconclusive.

Trial registration

At the same time, in September 2004, the International Committee of Medical Journal Editors (ICMJE) announced that all trials starting enrollment after July 1, 2005 must be registered prior to consideration for publication in one of the 12 member journals of the Committee.^[12] This move was to reduce the risk of publication bias as negative trials that are unpublished would be more easily discoverable.

Available trial registries include:

http://clinicaltrials.gov
World Health Organization's International Clinical Trial Registry Platform (ICTRP)
http://isrctn.org/

It is not clear how effective trial registration is because many registered trials are never completely published.^[144]

External validation

Judging external validity is more difficult than judging internal validity. "External validity refers to the question whether results are generalizable to persons other than the population in the original study."^[145] A framework for assessing external validity proposes:^[145]

"The study population might not be representative for the eligibility criteria that were intended. It should be addressed whether the study population differs from the intended source population with respect to characteristics that influence outcome."
"The target population will, by definition, differ from the study population with respect to geographical, temporal and ethnical conditions. Pondering external validity means asking the question whether these differences may influence study results."
"It should be assessed whether the study's conclusions can be generalized to target populations that do not meet all the eligibility criteria."

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@@ Line 16: / Line 16: @@
 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=19918557 | doi=10.1371/journal.pmed.1000131 }}</ref>
-In the [[United States]], Good Clinical Practices is overseen by the [[Food and Drug Administration]] (http://www.fda.gov/ScienceResearch/SpecialTopics/RunningClinicalTrials/).
+In the [[United States of America]], Good Clinical Practices is overseen by the [[Food and Drug Administration]] (http://www.fda.gov/ScienceResearch/SpecialTopics/RunningClinicalTrials/).
 ===Consort Statement===
@@ Line 40: / Line 40: @@
 The placebo effect can be seen in controlled trials of surgical interventions with the control group receiving a sham procedure.<ref name="pmid13657350">{{cite journal |author=Cobb LA, Thomas GI, Dillard DH, Merendino KA, Bruce RA |title=An evaluation of internal-mammary-artery ligation by a double-blind technic |journal=N. Engl. J. Med. |volume=260 |issue=22 |pages=1115–8 |year=1959 |month=May |pmid=13657350 |doi= |url= |issn=}}</ref><ref name="pmid13816818">{{cite journal |author=Dimond EG, Kittle CF, Crockett JE |title=Comparison of internal mammary artery ligation and sham operation for angina pectoris |journal=Am. J. Cardiol. |volume=5 |issue= |pages=483–6 |year=1960 |month=April |pmid=13816818 |doi= |url= |issn=}}</ref><ref name="pmid12110735">{{cite journal |author=Moseley JB, O'Malley K, Petersen NJ, ''et al'' |title=A controlled trial of arthroscopic surgery for osteoarthritis of the knee |journal=N. Engl. J. Med. |volume=347 |issue=2 |pages=81–8 |year=2002 |month=July |pmid=12110735 |doi=10.1056/NEJMoa013259 |url=http://content.nejm.org/cgi/pmidlookup?view=short&pmid=12110735&promo=ONFLNS19 |issn=}}</ref>
+Optimization of the delivery of health care in the control groups is important. This was illustrated in a randomized control trial of [[extracorporeal membrane oxygenation]] (ECMO). The ECO showed no improvement in survival although the survival of patients treated with ECMO was similar to prior published results.<ref name="pmid8306022">{{cite journal| author=Morris AH, Wallace CJ, Menlove RL, Clemmer TP, Orme JF, Weaver LK et al.| title=Randomized clinical trial of pressure-controlled inverse ratio ventilation and extracorporeal CO2 removal for adult respiratory distress syndrome. | journal=Am J Respir Crit Care Med | year= 1994 | volume= 149 | issue= 2 Pt 1 | pages= 295-305 | pmid=8306022 | doi=10.1164/ajrccm.149.2.8306022 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8306022  }} </ref> In this trial, the authors had protocolized the management of the [[mechanical ventilation]] in the control group and found high adherence to the protocols and higher than expected survival in the control group.  In a subsequent randomized controlled trial, the authors found that protocolized management [[mechanical ventilation]] of was better than usual care management of [[mechanical ventilation]].<ref name="pmid10566359">{{cite journal| author=East TD, Heermann LK, Bradshaw RL, Lugo A, Sailors RM, Ershler L et al.| title=Efficacy of computerized decision support for mechanical ventilation: results of a prospective multi-center randomized trial. | journal=Proc AMIA Symp | year= 1999 | volume=  | issue=  | pages= 251-5 | pmid=10566359 | doi= | pmc=PMC2232746 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10566359  }} </ref>
 The Hawthorne effect is the improvements seen in control subjects simply from participating in research.<ref name="pmid17608932">{{cite journal |author=McCarney R, Warner J, Iliffe S, van Haselen R, Griffin M, Fisher P |title=The Hawthorne Effect: a randomised, controlled trial |journal=BMC Med Res Methodol |volume=7 |issue= |pages=30 |year=2007 |pmid=17608932 |pmc=1936999 |doi=10.1186/1471-2288-7-30 |url=http://www.biomedcentral.com/1471-2288/7/30 |issn=}}</ref>
@@ Line 62: / Line 64: @@
 ===Delayed start trial===
-In this design, one group is randomized to receive treatment before the control group.<ref>D'Agostino, Ralph B., Sr. [http://content.nejm.org/cgi/content/full/361/13/1304 The Delayed-Start Study Design] N Engl J Med 2009 361: 1304-1306 PMID 19776413</ref> This design allows analysis for disease-modifying effects of treatments. An example of this design was a trial of [[rasagiline]] for [[Parkinson Disease]].<ref>Olanow, C. Warren, Rascol, Olivier, Hauser, Robert, Feigin, Paul D., Jankovic, Joseph, Lang, Anthony, Langston, William, Melamed, Eldad, Poewe, Werner, Stocchi, Fabrizio, Tolosa, Eduardo, the ADAGIO Study Investigators, [http://content.nejm.org/cgi/content/full/361/13/1268 A Double-Blind, Delayed-Start Trial of Rasagiline in Parkinson's Disease] N Engl J Med 2009 361: 1268-1278 PMID 19776408</ref>
+In this design, one group is randomized to receive treatment before the control group.<ref>D'Agostino, Ralph B., Sr. [http://content.nejm.org/cgi/content/full/361/13/1304 The Delayed-Start Study Design] N Engl J Med 2009 361: 1304-1306 PMID 19776413</ref> This design allows analysis for disease-modifying effects of treatments. An example of this design was a trial of [[rasagiline]] for [[Parkinson's disease]].<ref>Olanow, C. Warren, Rascol, Olivier, Hauser, Robert, Feigin, Paul D., Jankovic, Joseph, Lang, Anthony, Langston, William, Melamed, Eldad, Poewe, Werner, Stocchi, Fabrizio, Tolosa, Eduardo, the ADAGIO Study Investigators, [http://content.nejm.org/cgi/content/full/361/13/1268 A Double-Blind, Delayed-Start Trial of Rasagiline in Parkinson's Disease] N Engl J Med 2009 361: 1268-1278 PMID 19776408</ref>
 ===Dose ranging studies===
@@ Line 84: / Line 86: @@
 |}
-A factorial design allows two interventions to be be studied with ability to measure the treatment effect of each intervention in isolation and in combination.<ref name="pmid12759326">{{cite journal |author=McAlister FA, Straus SE, Sackett DL, Altman DG |title=Analysis and reporting of factorial trials: a systematic review |journal=JAMA |volume=289 |issue=19 |pages=2545–53 |year=2003 |month=May |pmid=12759326 |doi=10.1001/jama.289.19.2545 |url=http://jama.ama-assn.org/cgi/pmidlookup?view=long&pmid=12759326 |issn=}}</ref><ref name="pmid4023472">{{cite journal |author=Stampfer MJ, Buring JE, Willett W, Rosner B, Eberlein K, Hennekens CH |title=The 2 x 2 factorial design: its application to a randomized trial of aspirin and carotene in U.S. physicians |journal=Stat Med |volume=4 |issue=2 |pages=111–6 |year=1985 |pmid=4023472 |doi=10.1002/sim.4780040202 |url= |issn=}}</ref> Interaction between the two treatments can be displayed with "interaction ratios or odds ratios accompanied by their confidence intervals"<ref name="pmid12759326"/> and can be measured with the method of Gail and Simon<ref name="pmid4027319">{{cite journal| author=Gail M, Simon R| title=Testing for qualitative interactions between treatment effects and patient subsets. | journal=Biometrics | year= 1985 | volume= 41 | issue= 2 | pages= 361-72 | pmid=4027319
+A factorial design allows two interventions to be studied with ability to measure the treatment effect of each intervention in isolation and in combination.<ref name="pmid12759326">{{cite journal |author=McAlister FA, Straus SE, Sackett DL, Altman DG |title=Analysis and reporting of factorial trials: a systematic review |journal=JAMA |volume=289 |issue=19 |pages=2545–53 |year=2003 |month=May |pmid=12759326 |doi=10.1001/jama.289.19.2545 |url=http://jama.ama-assn.org/cgi/pmidlookup?view=long&pmid=12759326 |issn=}}</ref><ref name="pmid4023472">{{cite journal |author=Stampfer MJ, Buring JE, Willett W, Rosner B, Eberlein K, Hennekens CH |title=The 2 x 2 factorial design: its application to a randomized trial of aspirin and carotene in U.S. physicians |journal=Stat Med |volume=4 |issue=2 |pages=111–6 |year=1985 |pmid=4023472 |doi=10.1002/sim.4780040202 |url= |issn=}}</ref> Interaction between the two treatments can be displayed with "interaction ratios or odds ratios accompanied by their confidence intervals"<ref name="pmid12759326"/> and can be measured with the method of Gail and Simon<ref name="pmid4027319">{{cite journal| author=Gail M, Simon R| title=Testing for qualitative interactions between treatment effects and patient subsets. | journal=Biometrics | year= 1985 | volume= 41 | issue= 2 | pages= 361-72 | pmid=4027319
 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&email=badgett@uthscdsa.edu&retmode=ref&cmd=prlinks&id=4027319 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref> or the Breslow-Day test for homogeneity.
@@ Line 95: / Line 97: @@
 In an "N of 1" trial, also called a "single-subject randomized" trial, a single patient randomly proceeds through multiple blinded crossover comparisons. This address the concerns that traditional randomized controlled trials may not generalize to a specific patient.<ref name="pmid8616414">{{cite journal |author=Mahon J, Laupacis A, Donner A, Wood T |title=Randomised study of n of 1 trials versus standard practice |journal=BMJ |volume=312 |issue=7038 |pages=1069–74 |year=1996 |pmid=8616414 |doi= |issn=}}</ref>
-Underlining the difficulty in extrapolating from large trials to individual patients, Sackett proposed the use of N of 1 randomized controlled trials. In these, the patient is both the treatment group and the placebo group, but at different times. Blinding must be done with the collaboration of the pharmacist, and treatment effects must appear and disappear quickly following introduction and cessation of the therapy. This type of trial can be performed for many chronic, stable conditions.<ref name="pmid3409138">{{cite journal |author=Guyatt G ''et al'' |title=A clinician's guide for conducting randomized trials in individual patients |journal=CMAJ |volume=139  |pages=497–503 |year=1988 |pmid=3409138 |doi=}}</ref> The individualized nature of the single-subject randomized trial, and the fact that it often requires the active participation of the patient (questionnaires, diaries), appeals to the patient and promotes better insight and self-management<ref name="pmid17371593">{{cite journal |author=Brookes ST ''et al.'' |title="Me's me and you's you": Exploring patients' perspectives of single patient (n-of-1) trials in the UK |journal=Trials |volume=8  |pages=10 |year=2007 |pmid=17371593 |doi=10.1186/1745-6215-8-10}}</ref><ref name="pmid8299295">{{cite journal |author=Langer JC ''et al.'' |title=The single-subject randomized trial. A useful clinical tool for assessing therapeutic efficacy in pediatric practice |journal=Clinical Pediatrics |volume=32 |pages=654–7 |year=1993 |pmid=8299295 |doi=}}</ref> as well as patient safety,<ref name="pmid8616414">{{cite journal |author=Mahon J ''et al.'' |title=Randomised study of n of 1 trials versus standard practice |journal=BMJ |volume=312|pages=1069–74 |year=1996 |pmid=8616414 |doi=}}</ref> in a cost-effective manner.
+Underlining the difficulty in extrapolating from large trials to individual patients, Sackett proposed the use of N of 1 randomized controlled trials. In these, the patient is both the treatment group and the placebo group, but at different times. Blinding must be done with the collaboration of the pharmacist, and treatment effects must appear and disappear quickly following introduction and cessation of the therapy. This type of trial can be performed for many chronic, stable conditions.<ref name="pmid3409138">{{cite journal |author=Guyatt G ''et al'' |title=A clinician's guide for conducting randomized trials in individual patients |journal=CMAJ |volume=139  |pages=497–503 |year=1988 |pmid=3409138 |doi=}}</ref> The individualized nature of the single-subject randomized trial, and the fact that it often requires the active participation of the patient (questionnaires, diaries), appeals to the patient and promotes better insight and self-management<ref name="pmid17371593">{{cite journal |author=Brookes ST ''et al.'' |title="Me's me and you's you": Exploring patients' perspectives of single patient (n-of-1) trials in the UK |journal=Trials |volume=8  |pages=10 |year=2007 |pmid=17371593 |doi=10.1186/1745-6215-8-10}}</ref><ref name="pmid8299295">{{cite journal |author=Langer JC ''et al.'' |title=The single-subject randomized trial. A useful clinical tool for assessing therapeutic efficacy in pediatric practice |journal=Clinical Pediatrics |volume=32 |pages=654–7 |year=1993 |pmid=8299295 |doi=}}</ref> as well as patient safety,<ref name="pmid8616414"/> in a cost-effective manner.
 ===Noninferiority and equivalence randomized trials===
@@ Line 113: / Line 115: @@
 {{Image|Noninferiority and equivalency randomized controlled trials.jpg|right|350px|Noninferiority and equivalency randomized controlled trials.}}
-As stated in The [[Declaration of Helsinki]] by the [[World Medical Association]] it is unethical to give any patient a placebo treatment if an existing treatment option is known to be beneficial.<ref>{{cite web |url=http://www.wma.net/e/policy/b3.htm |title=Declaration of Helsinki: Ethical Principles for Medical Research Involving Human                      Subjects |author=World Medical Association|accessdate=2007-11-17 |format= |work=}}</ref><ref name="pmid9062334">{{cite journal |author= |title=World Medical Association declaration of Helsinki. Recommendations guiding physicians in biomedical research involving human subjects |journal=JAMA |volume=277 |pages=925–6 |year=1997 |pmid=9062334 |doi=}}</ref> Many scientists and ethicists consider that the U.S. [[Food and Drug Administration]], by demanding placebo-controlled trials, encourages the systematic violation of the Declaration of Helsinki.<ref name="pmid12812185">{{cite journal |author=Michels KB, Rothman KJ |title=Update on unethical use of placebos in randomised trials |journal=Bioethics |volume=17  |pages=188–204 |year=2003 |pmid=12812185 |doi=}}</ref> In addition, the use of placebo controls remains a convenient way to avoid direct comparisons with a competing drug.
+As stated in The [[Declaration of Helsinki]] by the [[World Medical Association]] it is unethical to give any patient a placebo treatment if an existing treatment option is known to be beneficial.<ref>{{cite web |url=http://www.wma.net/e/policy/b3.htm |title=Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects |author=World Medical Association|accessdate=2007-11-17 |format= |work=}}</ref><ref name="pmid9062334">{{cite journal |author= |title=World Medical Association declaration of Helsinki. Recommendations guiding physicians in biomedical research involving human subjects |journal=JAMA |volume=277 |pages=925–6 |year=1997 |pmid=9062334 |doi=}}</ref> Many scientists and ethicists consider that the U.S. [[Food and Drug Administration]], by demanding placebo-controlled trials, encourages the systematic violation of the Declaration of Helsinki.<ref name="pmid12812185">{{cite journal |author=Michels KB, Rothman KJ |title=Update on unethical use of placebos in randomised trials |journal=Bioethics |volume=17  |pages=188–204 |year=2003 |pmid=12812185 |doi=}}</ref> In addition, the use of placebo controls remains a convenient way to avoid direct comparisons with a competing drug.
 The appropriate use of placebo is being revised.<ref name="pmid10975964">{{cite journal |author=Temple R, Ellenberg SS |title=Placebo-controlled trials and active-control trials in the evaluation of new treatments. Part 1: ethical and scientific issues |journal=Ann Intern Med |volume=133 |pages=455–63 |year=2000 |pmid=10975964 |doi=|url=http://www.annals.org/cgi/content/full/133/6/455}}</ref><ref name="pmid10975965">{{cite journal |author=Ellenberg SS, Temple R |title=Placebo-controlled trials and active-control trials in the evaluation of new treatments. Part 2: practical issues and specific cases |journal=Ann Intern Med |volume=133  |pages=464–70 |year=2000 |pmid=10975965 |doi=|url=http://www.annals.org/cgi/content/full/133/6/464}}</ref> When guidelines suggest a placebo is an unethical control, then an "active-control noninferiority trial" may be used.<ref name="pmid16818930">{{cite journal |author=Kaul S, Diamond GA |title=Good enough: a primer on the analysis and interpretation of noninferiority trials |journal=Ann Intern Med |volume=145 |pages=62–9 |year=2006 |pmid=16818930 |doi=|url=http://www.annals.org/cgi/content/full/145/1/62}}</ref> To establish non-inferiority, the following three conditions should be - but frequently are not - established:<ref name="pmid16818930"/>
@@ Line 120: / Line 122: @@
 # "The treatment offers ancillary advantages in safety, tolerability, cost, or convenience."
-Noninferiority and equivalence randomized trial are difficult to execute well.<ref name="pmid16818930">{{cite journal |author=Kaul S, Diamond GA |title=Good enough: a primer on the analysis and interpretation of noninferiority trials |journal=Ann. Intern. Med. |volume=145 |issue=1 |pages=62–9 |year=2006 |pmid=16818930 |doi= |issn=}}</ref> Guidelines exists for noninferiority and equivalence randomized trials.<ref name="pmid16522836">{{cite journal |author=Piaggio G, Elbourne DR, Altman DG, Pocock SJ, Evans SJ |title=Reporting of noninferiority and equivalence randomized trials: an extension of the CONSORT statement |journal=JAMA |volume=295 |issue=10 |pages=1152–60 |year=2006 |pmid=16522836 |doi=10.1001/jama.295.10.1152 |issn=}}</ref> In planning the trial, the investigators should choose "a noninferiority or equivalence criterion, and specifying the margin of equivalence with the rationale for its choice."<ref name="pmid16522836"/> In reporting the outcomes, the authors should present the confidence intervals to show the reader whether the result was within their noninferiority or equivalence criterion.<ref name="pmid16522836"/>
+Noninferiority and equivalence randomized trial are difficult to execute well.<ref name="pmid16818930"/> Guidelines exists for noninferiority and equivalence randomized trials.<ref name="pmid16522836">{{cite journal |author=Piaggio G, Elbourne DR, Altman DG, Pocock SJ, Evans SJ |title=Reporting of noninferiority and equivalence randomized trials: an extension of the CONSORT statement |journal=JAMA |volume=295 |issue=10 |pages=1152–60 |year=2006 |pmid=16522836 |doi=10.1001/jama.295.10.1152 |issn=}}</ref> In planning the trial, the investigators should choose "a noninferiority or equivalence criterion, and specifying the margin of equivalence with the rationale for its choice."<ref name="pmid16522836"/> In reporting the outcomes, the authors should present the confidence intervals to show the reader whether the result was within their noninferiority or equivalence criterion.<ref name="pmid16522836"/>
 ===Add-on design===
@@ Line 129: / Line 131: @@
 [http://www.consort-statement.org/ Consort] has described pragmatic trials and standards for their reporting.<ref name="pmid19001484">{{cite journal |author=Zwarenstein M, Treweek S, Gagnier JJ, ''et al'' |title=Improving the reporting of pragmatic trials: an extension of the CONSORT statement |journal=BMJ |volume=337 |issue= |pages=a2390 |year=2008 |pmid=19001484 |doi= |url=http://bmj.com/cgi/pmidlookup?view=long&pmid=19001484 |issn=}}</ref> CONSORT describes a pragmatic trial as addressing "does the intervention work when used in normal practice" as opposed to an "explanatory trial" that addresses "can the intervention work." CONSORT states that this is not a dichotomy of trial designs, but that pragmatic trials reflect an attitude in the design. CONSORT offers an example of a pragmatic trial<ref name="pmid16980316">{{cite journal |author=Thomas KJ, MacPherson H, Thorpe L, ''et al'' |title=Randomised controlled trial of a short course of traditional acupuncture compared with usual care for persistent non-specific low back pain |journal=BMJ |volume=333 |issue=7569 |pages=623 |year=2006 |month=September |pmid=16980316 |pmc=1570824 |doi=10.1136/bmj.38878.907361.7C |url=http://bmj.com/cgi/pmidlookup?view=long&pmid=16980316 |issn=}}</ref> and an explanatory trial.<ref name="pmid1852179">{{cite journal |author= |title=Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators |journal=N. Engl. J. Med. |volume=325 |issue=7 |pages=445–53 |year=1991 |month=August |pmid=1852179 |doi= |url= |issn=}}</ref>
-The [[cohort multiple randomized controlled trial]] may be a practical variation of this design.<ref>{{Cite journal
+The [[cohort multiple randomized controlled trial]] may be a practical variation of this design.<ref name="pmid20304934">{{cite journal| author=Relton C, Torgerson D, O'Cathain A, Nicholl J| title=Rethinking pragmatic randomised controlled trials: introducing the "cohort multiple randomised controlled trial" design. | journal=BMJ | year= 2010 | volume= 340 | issue=  | pages= c1066 | pmid=20304934 | doi=10.1136/bmj.c1066 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20304934  }} </ref>
-| doi = 10.1136/bmj.c1066
-| volume = 340
-| issue = mar19_1
-| pages = c1066
-| last = Relton
-| first = Clare
-| coauthors = David Torgerson, Alicia O'Cathain, Jon Nicholl
-| title = Rethinking pragmatic randomised controlled trials: introducing the "cohort multiple randomised controlled trial" design
-| journal = BMJ
-| accessdate = 2010-03-25
-| date = 2010-03-24
-| url = http://www.bmj.com
-}}</ref>
 ==Ethical issues==
 ===Background===
 The  Belmont Report was released in 1979 by the National Commission for the Protection of Human Subjects in Biomedical and  Behavioral Research.<ref>[http://www.hhs.gov/ohrp/humansubjects/guidance/belmont.html The Belmont Report]. U.S. Department of Health & Human Services</ref><ref>[http://ohsr.od.nih.gov/guidelines/belmont.html The Belmont Report]. National Institutes of Health</ref> The three Belmont principles are beneficence, justice and respect for persons.
@@ Line 183: / Line 171: @@
 There are times when placebo control is appropriate even when there is accepted, effective treatment.<ref name="pmid10975964">{{cite journal |author=Temple R, Ellenberg SS |title=Placebo-controlled trials and active-control trials in the evaluation of new treatments. Part 1: ethical and scientific issues |journal=Ann Intern Med |volume=133 |pages=455–63 |year=2000 |pmid=10975964 |doi=|url=http://www.annals.org/cgi/content/full/133/6/455}}</ref><ref name="pmid10975965">{{cite journal |author=Ellenberg SS, Temple R |title=Placebo-controlled trials and active-control trials in the evaluation of new treatments. Part 2: practical issues and specific cases |journal=Ann Intern Med |volume=133  |pages=464–70 |year=2000 |pmid=10975965 |doi=|url=http://www.annals.org/cgi/content/full/133/6/464}}</ref><ref name="pmid11565527">{{cite journal |author=Emanuel EJ, Miller FG |title=The ethics of placebo-controlled trials--a middle ground |journal=N. Engl. J. Med. |volume=345 |issue=12 |pages=915–9 |year=2001 |pmid=11565527 |doi=}}</ref>
-There are ethical concerns in comparing a surgical intervention to sham surgery; however, this has been done.<ref>Cobb LA, Thomas GI, Dillard DH, Merendino KA, Bruce RA: An evaluation of internal-mammary-artery ligation by a double-blind technique. N Engl J Med 1959;260:1115-1118.</ref><ref name="pmid12110735">{{cite journal |author=Moseley JB, O'Malley K, Petersen NJ, ''et al'' |title=A controlled trial of arthroscopic surgery for osteoarthritis of the knee |journal=N. Engl. J. Med. |volume=347 |issue=2 |pages=81–8 |year=2002 |pmid=12110735 |doi=10.1056/NEJMoa013259}}</ref> Guidelines by the [[American Medical Association]] address the use of placebo surgery.<ref name="pmid11807373">{{cite journal |author=Tenery R, Rakatansky H, Riddick FA, ''et al'' |title=Surgical "placebo" controls |journal=Ann. Surg. |volume=235 |issue=2 |pages=303–7 |year=2002 |pmid=11807373 |doi=}}</ref>
+There are ethical concerns in comparing a surgical intervention to sham surgery; however, this has been done.<ref>Cobb LA, Thomas GI, Dillard DH, Merendino KA, Bruce RA: An evaluation of internal-mammary-artery ligation by a double-blind technique. N Engl J Med 1959;260:1115-1118.</ref><ref name="pmid12110735"/> Guidelines by the [[American Medical Association]] address the use of placebo surgery.<ref name="pmid11807373">{{cite journal |author=Tenery R, Rakatansky H, Riddick FA, ''et al'' |title=Surgical "placebo" controls |journal=Ann. Surg. |volume=235 |issue=2 |pages=303–7 |year=2002 |pmid=11807373 |doi=}}</ref>
 ===Interim analysis - stopping trials early===
@@ Line 208: / Line 196: @@
 ====Seeding trials====
-Seeding trials are studies sponsored by industry whose "apparent purpose is to test a hypothesis. The true purpose is to get physicians in the habit of prescribing a new drug."<ref name="pmid18711155">{{cite journal |author=Hill KP, Ross JS, Egilman DS, Krumholz HM |title=The ADVANTAGE seeding trial: a review of internal documents |journal=Ann. Intern. Med. |volume=149 |issue=4 |pages=251–8 |year=2008 |month=August |pmid=18711155 |doi= |url=http://www.annals.org/cgi/pmidlookup?view=long&pmid=18711155 |issn=}}</ref> Examples include the ADVANTAGE<ref name="pmid18711155">{{cite journal| author=Hill KP, Ross JS, Egilman DS, Krumholz HM| title=The ADVANTAGE seeding trial: a review of internal documents. | journal=Ann Intern Med | year= 2008 | volume= 149 | issue= 4 | pages= 251-8 | pmid=18711155 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18711155  }} </ref> and STEPS<ref name="pmid21709111">{{cite journal| author=Krumholz SD, Egilman DS, Ross JS| title=Study of neurontin: titrate to effect, profile of safety (STEPS) trial: a narrative account of a gabapentin seeding trial. | journal=Arch Intern Med | year= 2011 | volume= 171 | issue= 12 | pages= 1100-7 | pmid=21709111 | doi=10.1001/archinternmed.2011.241 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21709111  }} </ref> trials.
+Seeding trials are studies sponsored by industry whose "apparent purpose is to test a hypothesis. The true purpose is to get physicians in the habit of prescribing a new drug."<ref name="pmid18711155">{{cite journal |author=Hill KP, Ross JS, Egilman DS, Krumholz HM |title=The ADVANTAGE seeding trial: a review of internal documents |journal=Ann. Intern. Med. |volume=149 |issue=4 |pages=251–8 |year=2008 |month=August |pmid=18711155 |doi= |url=http://www.annals.org/cgi/pmidlookup?view=long&pmid=18711155 |issn=}}</ref> Examples include the ADVANTAGE<ref name="pmid18711155"/> and STEPS<ref name="pmid21709111">{{cite journal| author=Krumholz SD, Egilman DS, Ross JS| title=Study of neurontin: titrate to effect, profile of safety (STEPS) trial: a narrative account of a gabapentin seeding trial. | journal=Arch Intern Med | year= 2011 | volume= 171 | issue= 12 | pages= 1100-7 | pmid=21709111 | doi=10.1001/archinternmed.2011.241 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21709111  }} </ref> trials.
 ==Measuring outcomes==
@@ Line 309: / Line 297: @@
 ===Cochrane bias scale===
-The Cochrane Collaboration uses a six item tool.<ref>Higgins JPT, Green S (editors). [http://www.mrc-bsu.cam.ac.uk/cochrane/handbook/chapter_8/table_8_5_a_the_cochrane_collaborations_tool_for_assessing.htm Table 8.5.a: The Cochrane Collaboration's Tool for assessing risk of bias]. [http://www.cochrane-handbook.org/ Cochrane Handbook for Systematic Reviews of Interventions] Version 5.0.1 [updated September 2008]. The Cochrane Collaboration, 2008. Available from [http://www.cochrane-handbook.org/ www.cochrane-handbook.org].</ref> Trials that have high or uncertain bias are more likely to report large effect sizes.<ref name="pmid19841007">{{cite journal| author=Hartling L, Ospina M, Liang Y, Dryden DM, Hooton N, Krebs Seida J et al.| title=Risk of bias versus quality assessment of randomised controlled trials: cross sectional study. | journal=BMJ | year= 2009 | volume= 339 | issue=  | pages= b4012 | pmid=19841007
+The Cochrane Collaboration uses a six item tool.<ref>Higgins JPT, Green S (editors). [http://handbook.cochrane.org/chapter_8/8_5_the_cochrane_collaborations_tool_for_assessing_risk_of_bias.htm 8.5  The Cochrane Collaboration’s tool for assessing risk of bias]. [http://www.cochrane-handbook.org/ Cochrane Handbook for Systematic Reviews of Interventions] Version 5.1.0 updated March 2011. The Cochrane Collaboration, 2011. Available from http://handbook.cochrane.org.</ref> Trials that have high or uncertain bias are more likely to report large effect sizes.<ref name="pmid19841007">{{cite journal| author=Hartling L, Ospina M, Liang Y, Dryden DM, Hooton N, Krebs Seida J et al.| title=Risk of bias versus quality assessment of randomised controlled trials: cross sectional study. | journal=BMJ | year= 2009 | volume= 339 | issue=  | pages= b4012 | pmid=19841007
 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=19841007 | doi=10.1136/bmj.b4012 }}</ref>
@@ Line 367: / Line 355: @@
 ==References==
-{{reflist}}
+<small>
+<references>
+</references>
+</small>
+[[Category:Suggestion Bot Tag]]

Randomized controlled trial: Difference between revisions

Latest revision as of 07:36, 31 October 2024

Major developments in randomized controlled trials

International Conference on Harmonization

Consort Statement

Trial registration

Disclosure of Competing Interests

Control group

Blinding

Variations in design

Cluster-randomized trials

Before-after studies

Crossover trial

Delayed start trial

Dose ranging studies

Factorial design

N of 1 trial

Noninferiority and equivalence randomized trials

Add-on design

Pragmatic trials

Ethical issues

Background

Ethics of randomizing subjects

Interim analysis - stopping trials early

Unnecessary trials

Seeding trials

Measuring outcomes

Missing data

Crossover between experimental groups

Surrogate outcomes

Composite outcomes

Overdiagnosis

Adverse outcomes

Analysis

Planning analyses prior to conducting the trial

Conflict-of-interests in data analyses

Subgroup analyses

Assessing the quality of a trial

Cochrane bias scale

Jadad score

Schulz

Studies of characteristics of trails

Problems with trials

Small study effect

Publication bias=

Trial registration

External validation

References

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