Apolipoprotein E4: Difference between revisions
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In [[medicine]], '''apolipoprotein E4''' (apolipoprotein ε4) is an [[apolipoprotein]] which is "a major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from apolipoprotein E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for [[Alzheimer's disease|Alzheimer disease]] and [[cardiovascular disease]]s.<ref>{{MeSH}}</ref> | In [[medicine]], '''apolipoprotein E4''' (apolipoprotein ε4) is an [[apolipoprotein]] which is "a major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from apolipoprotein E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for [[Alzheimer's disease|Alzheimer disease]] and [[cardiovascular disease]]s.<ref>{{MeSH}}</ref> | ||
==Epidemiology== | |||
In the [[Framingham Heart Study]] found:<ref name="pmid8618665">{{cite journal| author=Myers RH, Schaefer EJ, Wilson PW, D'Agostino R, Ordovas JM, Espino A et al.| title=Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study. | journal=Neurology | year= 1996 | volume= 46 | issue= 3 | pages= 673-7 | pmid=8618665 | doi= | pmc= | url= }} </ref> | |||
{| class="wikitable" | |||
|+ Risk of [[Alzheimer's disease]] in the [[Framingham Heart Study]] | |||
! heading !! Prevalence of [[Alzheimer's disease]] by age 80 or 85 | |||
|- | |||
| ApoE epsilon4/epsilon4 homozygotes || align=center|55% | |||
|- | |||
| ApoE epsilon3/epsilon4 heterozygotes||align=center| 27% | |||
|- | |||
| No apoE epsilon4 alleles|| align=center|9% | |||
|} | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 10:37, 10 November 2011
In medicine, apolipoprotein E4 (apolipoprotein ε4) is an apolipoprotein which is "a major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from apolipoprotein E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for Alzheimer disease and cardiovascular diseases.[1]
Epidemiology
In the Framingham Heart Study found:[2]
| heading | Prevalence of Alzheimer's disease by age 80 or 85 |
|---|---|
| ApoE epsilon4/epsilon4 homozygotes | 55% |
| ApoE epsilon3/epsilon4 heterozygotes | 27% |
| No apoE epsilon4 alleles | 9% |
References
- ↑ Anonymous (2024), Apolipoprotein E4 (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Myers RH, Schaefer EJ, Wilson PW, D'Agostino R, Ordovas JM, Espino A et al. (1996). "Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study.". Neurology 46 (3): 673-7. PMID 8618665. [e]