Monoclonal antibody: Difference between revisions
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antibodies | year = 2008 | url = http://www.ifpma.org/fileadmin/templates/ifpmaissues/pdfs/2008_03_21_IFPMA_Proposal_for_naming_of_new_monoclonals.pdf}}</ref> | antibodies | year = 2008 | url = http://www.ifpma.org/fileadmin/templates/ifpmaissues/pdfs/2008_03_21_IFPMA_Proposal_for_naming_of_new_monoclonals.pdf}}</ref> | ||
Naming of monoclonal antibodies is governed by [[World Health Organization]]’s [http://www.who.int/medicines/services/inn/en/ International Nonproprietary Name] (INN): | |||
* [[Humanized monoclonal antibody]]. | * [[Human monoclonal antibody]]. INN names end in -umab. Example is [[olaratumab]]. | ||
* [[Chimeric monoclonal antibody]]. | * [[Humanized monoclonal antibody]]. INN names end in -zumab. Example is [[benralizumab]]. | ||
* [[Chimeric monoclonal antibody]]. INN names end in -ximab. Example is [[rituximab]]. | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 08:00, 26 April 2014
A monoclonal antibody is an immune substance "produced by clones of cells such as those isolated after hybridization of activated B-lymphocytes with neoplastic cells. These hybrids are often referred to as hybridomas." [1] Monoclonal antibodies have extensive applications in clinical medicine and immunochemistry.
The World Health Organization is refining naming conventions for monoclonal antibodies. [2] Its original system came from the International Federation of Pharmaceutical Manufacturers & Associations (IFPMA) Biotech Working Group.[3]
Naming of monoclonal antibodies is governed by World Health Organization’s International Nonproprietary Name (INN):
- Human monoclonal antibody. INN names end in -umab. Example is olaratumab.
- Humanized monoclonal antibody. INN names end in -zumab. Example is benralizumab.
- Chimeric monoclonal antibody. INN names end in -ximab. Example is rituximab.
References
- ↑ Anonymous (2024), Antibody, monoclonal (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Anna-Maija Autere, Nicole Wagner and Georg-Burkhard Kresse from Roche on behalf of International Federation of Pharmaceutical Manufacturers & Associations (IFPMA) Biotech Working Group (2008), "International Nonproprietary Names for monoclonal antibodies: IFPMA proposal", WHO Drug Information 22 (2), pp. 97-107
- ↑ International Federation of Pharmaceutical Manufacturers & Associations (IFPMA) Biotech Working Group (2008), [http://www.ifpma.org/fileadmin/templates/ifpmaissues/pdfs/2008_03_21_IFPMA_Proposal_for_naming_of_new_monoclonals.pdf Proposal to the WHO INN Expert Group: Principles for naming of new monoclonal antibodies]