Antineutrophil cytoplasmic antibodies: Difference between revisions
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In [[medicine]] and [[rheumatology]], '''antineutrophil cytoplasmic antibodies''' ('''ANCA''') are "[[Autoantibody|Autoantibodies]] directed against cytoplasmic constituents of polymorphonuclear leukocytes and/or monocytes. They are used as specific markers for [[Wegener Granulomatosi]]s and other diseases, though their pathophysiological role is not clear. ANCA are routinely detected by [[indirect immunofluorescence]] with three different patterns: c-ANCA (cytoplasmic), p-ANCA (perinuclear), and atypical ANCA."<ref>{{MeSH}}</ref> | In [[medicine]] and [[rheumatology]], '''antineutrophil cytoplasmic antibodies''' ('''ANCA''') are "[[Autoantibody|Autoantibodies]] directed against cytoplasmic constituents of polymorphonuclear leukocytes and/or monocytes. They are used as specific markers for [[Wegener Granulomatosi]]s and other diseases, though their pathophysiological role is not clear. ANCA are routinely detected by [[indirect immunofluorescence]] with three different patterns: c-ANCA (cytoplasmic), p-ANCA (perinuclear), and atypical ANCA."<ref>{{MeSH}}</ref> | ||
ANCA is also seen in [[microscopic polyangiitis]] and [[Churg-Strauss syndrome]]. | ANCA is also seen in [[vasculitis|vasculitides]] such as [[microscopic polyangiitis]] and [[Churg-Strauss syndrome]], and peripheral ANCA may be present in [[inflammatory bowel disease]]. | ||
Types of ANCA are:<ref name="pmid16876669">{{cite journal| author=Bosch X, Guilabert A, Font J| title=Antineutrophil cytoplasmic antibodies. | journal=Lancet | year= 2006 | volume= 368 | issue= 9533 | pages= 404-18 | pmid=16876669 | Types of ANCA are:<ref name="pmid16876669">{{cite journal| author=Bosch X, Guilabert A, Font J| title=Antineutrophil cytoplasmic antibodies. | journal=Lancet | year= 2006 | volume= 368 | issue= 9533 | pages= 404-18 | pmid=16876669 | ||
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* proteinase 3 ANCA usually gives a cytoplasmic pattern (C-ANCA) | * proteinase 3 ANCA usually gives a cytoplasmic pattern (C-ANCA) | ||
ANCA are detected by [[Fluorescent antibody technique|indirect immunofluorescence]] and [[ | ANCA are detected by [[Fluorescent antibody technique|indirect immunofluorescence]] and [[enzyme-linked immunosorbent assay]] (ELISA). | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 15:41, 2 August 2010
In medicine and rheumatology, antineutrophil cytoplasmic antibodies (ANCA) are "Autoantibodies directed against cytoplasmic constituents of polymorphonuclear leukocytes and/or monocytes. They are used as specific markers for Wegener Granulomatosis and other diseases, though their pathophysiological role is not clear. ANCA are routinely detected by indirect immunofluorescence with three different patterns: c-ANCA (cytoplasmic), p-ANCA (perinuclear), and atypical ANCA."[1]
ANCA is also seen in vasculitides such as microscopic polyangiitis and Churg-Strauss syndrome, and peripheral ANCA may be present in inflammatory bowel disease.
Types of ANCA are:[2]
- myeloperoxidase ANCA usually gives a perinuclear pattern (P-ANCA)
- proteinase 3 ANCA usually gives a cytoplasmic pattern (C-ANCA)
ANCA are detected by indirect immunofluorescence and enzyme-linked immunosorbent assay (ELISA).
References
- ↑ Anonymous (2024), Antineutrophil cytoplasmic antibodies (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Bosch X, Guilabert A, Font J (2006). "Antineutrophil cytoplasmic antibodies.". Lancet 368 (9533): 404-18. DOI:10.1016/S0140-6736(06)69114-9. PMID 16876669. Research Blogging.