Gemfibrozil: Difference between revisions
Jump to navigation
Jump to search
imported>David E. Volk (New page: {{subpages}} right|thumb|200px|{{#ifexist:Template:Gemfibrozil structure.jpg/credit|{{Gemfibrozil structure.jpg/credit}}<br/>|}}Gemfibrozil. '''Gemfib...) |
imported>David E. Volk (brand names) |
||
| Line 3: | Line 3: | ||
'''Gemfibrozil''', or 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid), is drug that lowers serum [[triglyceride]] levels, with variable effects on cholesterol. The [[VLDL]] fraction is preferentially lowered and LDL less so. The HDL subfractions HDL2 and HDL3, and [[apolipoprotein]]s A-I and A-II, are increased. Gemfibrozil is a [[fibric acid]] antilipemic drug similar to [[clofibrate]] that is used to treat [[hyperlipoproteinemia]] and supplimental therapy for type IIb [[hypercholesterolemia]]. Gemfibrozil increases lipoprotein triglyceride lipolysis by increasing the activity of extrahepatic [[lipoprotein lipase]]. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. | '''Gemfibrozil''', or 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid), is drug that lowers serum [[triglyceride]] levels, with variable effects on cholesterol. The [[VLDL]] fraction is preferentially lowered and LDL less so. The HDL subfractions HDL2 and HDL3, and [[apolipoprotein]]s A-I and A-II, are increased. Gemfibrozil is a [[fibric acid]] antilipemic drug similar to [[clofibrate]] that is used to treat [[hyperlipoproteinemia]] and supplimental therapy for type IIb [[hypercholesterolemia]]. Gemfibrozil increases lipoprotein triglyceride lipolysis by increasing the activity of extrahepatic [[lipoprotein lipase]]. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. | ||
== Brand Names == | |||
*Apo-Gemfibrozil | |||
*Bolutol | |||
*Cholespid | |||
*Decrelip | |||
*Fibratol | |||
*Fibrocit | |||
*Gemfibril | |||
*Gemfibromax | |||
*Gemlipid | |||
*Gen-Fibro | |||
*Genlip | |||
*Gevilon | |||
*Hipolixan | |||
*Jezil | |||
*Lipozid | |||
*Lipur | |||
*Lopid | |||
*Novo-Gemfibrozil | |||
*Nu-Gemfibrozil | |||
== External Links == | == External Links == | ||
*{{DailyMed}} | *{{DailyMed}} | ||
*Drug Bank at http://www.drugbank.ca/cgi-bin/getCard.cgi?CARD=DB01241.txt | *Drug Bank at http://www.drugbank.ca/cgi-bin/getCard.cgi?CARD=DB01241.txt | ||
Revision as of 10:10, 25 January 2008
Gemfibrozil, or 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid), is drug that lowers serum triglyceride levels, with variable effects on cholesterol. The VLDL fraction is preferentially lowered and LDL less so. The HDL subfractions HDL2 and HDL3, and apolipoproteins A-I and A-II, are increased. Gemfibrozil is a fibric acid antilipemic drug similar to clofibrate that is used to treat hyperlipoproteinemia and supplimental therapy for type IIb hypercholesterolemia. Gemfibrozil increases lipoprotein triglyceride lipolysis by increasing the activity of extrahepatic lipoprotein lipase. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL.
Brand Names
- Apo-Gemfibrozil
- Bolutol
- Cholespid
- Decrelip
- Fibratol
- Fibrocit
- Gemfibril
- Gemfibromax
- Gemlipid
- Gen-Fibro
- Genlip
- Gevilon
- Hipolixan
- Jezil
- Lipozid
- Lipur
- Lopid
- Novo-Gemfibrozil
- Nu-Gemfibrozil
External Links
- Gemfibrozil - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Drug Bank at http://www.drugbank.ca/cgi-bin/getCard.cgi?CARD=DB01241.txt