Talk:Fetal programming

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Revision as of 15:09, 30 April 2013 by imported>Anthony.Sebastian (Attn: Gareth Leng)
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 Definition:  Refers to adaptations made by a fetus in response to adverse or beneficial intrauterine environments, adaptations targeting the fetus’s survival, adaptations that affect fetal structure and function during the highly plastic period of embryonic/fetal development, adaptations that persist after birth and that influence the structural, metabolic and physiological characteristics of the individual throughout life, which system characteristics can predispose the individual in later life to maladaptations in response to environmental conditions differing from those to which the fetus had adapted. [d] [e]
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 Workgroup categories:  Health Sciences, Biology and Psychology [Categories OK]
 Talk Archive:  none  English language variant:  American English

DOHaD researcher, Michael Meaney

- You might want to take a look at Michael Meaney's work - he's arguably the biggest name in this field in rat work - see e.g. http://www.ncbi.nlm.nih.gov/pubmed/21420958 and

Hackman DA, Farah MJ, Meaney MJ (2010) Socioeconomic status and the brain: mechanistic insights from human and animal research. Nat Rev Neurosci11:651-9 "Human brain development occurs within a socioeconomic context and childhood socioeconomic status (SES) influences neural development--particularly of the systems that subserve language and executive function. Research in humans and in animal models has implicated prenatal factors, parent-child interactions and cognitive stimulation in the home environment in the effects of SES on neural development. These findings provide a unique opportunity for understanding how environmental factors can lead to individual differences in brain development, and for improving the programmes and policies that are designed to alleviate SES-related disparities in mental health and academic achievement."Gareth Leng 14:03, 30 April 2013 (UTC)

Thanks, Gareth. I grabbed 60 references from PubMed with must-read-inducing titles, planning to study one-a-day. I started Fetal programming as a writing-to-learn exercise, and plan to start the parent topic, Developmental origins of health and disease, sometime soon. Much of Meaney's work will apply there, too, as he has extensively studied post-natal programming by maternal and parental care.
Biology never ceases to amaze.
I welcome your collaboration with either project. Anthony.Sebastian 21:09, 30 April 2013 (UTC)
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