Paroxetine

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In medicine, paroxetine is a second-generation antidepressant used for treating major depression. Its pharmacological action is a serotonin uptake inhibitor.

Pharmacology

Administration

Distribution

Metabolism

Paroxetine is metabolized in the liver by cytochrome P-450 CYP2D6.

Excretion

Toxicity

Drug interactions

Paroxetine may increase death from breast cancer among women taking tamoxifen due to inhibiting metabolism of tamoxifen to its active metabolite by cytochrome P-450 CYP2D6.[1]

References

  1. ↑ Kelly, Catherine M; David N Juurlink, Tara Gomes, Minh Duong-Hua, Kathleen I Pritchard, Peter C Austin, Lawrence F Paszat (2010-02-08). "Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study". BMJ 340 (feb08_1): c693. DOI:10.1136/bmj.c693. Retrieved on 2010-02-10. Research Blogging.
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