Talk:Pseudomembranous enterocolitis

Any sense of veterinary methods?

My cat is undergoing palliative chemotherapy with carboplatin. The tertiary care facility dispensed metronidazole, to use at the first sign of diarrhea. Is therapy this aggressive indicated in humans, even informally, or perhaps in pediatrics? Howard C. Berkowitz 03:28, 20 April 2010 (UTC)

Flagyl (metronidazole) is used to treat C. Difficile. The new IDSA guidelines for C. Difficile are not out yet. The poster presentation at the national IDSA 2006 Chicago conference will likely be the backbone for the new guidelines... and they will likely be Flagyl for mild C. Diff, Vanco for moderate and severe C. Diff. In humans, we usually do not empirically treat diarrhea unless the patient is already on antibiotics (which can kill normal flora which keeps C. Diff bacteria "in check" in those who are carriers). Ideally, we would have a stool toxin positive before we treat, but in complex patients we will start C. Diff if we suspect it as a possibility. I've not heard it for diarrhea related to chemo though... doesn't sound like the full story from the 1 liner case you presented - either bad medicine or incomplete thought process on why to use flagyl for diarrhea after chemo. Tom Kelly 03:41, 20 April 2010 (UTC)