Model organism/Bibliography

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• Bohland JW, Wu C, Barbas H, Bokil H, Bota M, Breiter HC et al. (2009). "A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale". PLoS Comput Biol 5 (3): e1000334. DOI:10.1371/journal.pcbi.1000334. PMID 19325892. PMC PMC2655718. Research Blogging. ^[e]

Suggests a framework for the study of the brain in model organisms at a mesoscopic scale, i.e. at length scales between the microscopic (≤ 100μm) and macroscopic (≥ several mm) levels. Based on the experience with the impact of wide-spread data sharing in other scientific disciplines (e.g. genomics), the criteria for a centralized knowledge repository on mesoscopic aspects of the brain in the rat, the macaque and humans are laid out.

• Lein, Ed S.; Michael J. Hawrylycz & Nancy Ao et al. (2007), "Genome-wide atlas of gene expression in the adult mouse brain", Nature 445 (7124): 168–176, DOI:10.1038/nature05453 ^[e]

Provides a brief description of The Allen Brain Atlas of the adult mouse brain (strain C57BL/6J) - "a genome-scale collection of cellular resolution gene expression profiles using in situ hybridization" of over 20,000 genes (i.e. most mouse genes then known to encode proteins). Also reports that "approximately 80% of total genes assayed display some cellular expression above background in the brain."

• Santini, F. & E.J. Stellwag (2002), "Phylogeny, fossils, and model systems in the study of evolutionary developmental biology", Molecular Phylogenetics and Evolution 24 (3): 379–383, DOI:10.1016/S1055-7903(02)00209-9 ^[e]
• Ballatori, N. & A.R. Villalobos (2002), "Defining the Molecular and Cellular Basis of Toxicity Using Comparative Models", Toxicology and Applied Pharmacology 183 (3): 207–220, DOI:10.1006/taap.2002.9488 ^[e]
• Bolker, J.A. (1995), "Model systems in developmental biology", BioEssays 17 (5): 451–455, DOI:10.1002/bies.950170513 ^[e]
• Krebs, H.A. (1975), "The August Krogh principle:"For many problems there is an animal on which it can be most conveniently studied"", J Exp Zool 194 (1): 221–6, DOI:10.1002/jez.1401940115 ^[e]