Mephenytoin

mephenytoin
IUPAC name: 5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione Synonyms: mephentoin, methyl hydantoin, methylphenetoin Formula: C12H14N2O2
Uses:	anti-seizure drug
Properties:
Hazards:
Mass (g/mol): CAS #: 218.2518 50-12-4

Mephenytoin (Mesantoin®) is an anticonvulsant medication used to treat epilepsy and it is particularly effective in tonic-clonic epilepsy . Its common chemical name is 3-methyl 5,5-phenyl-ethyl-hydantoin and its IUPAC chemical name is 5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione. It has pharmacological effects similar to phenytoin and the barbiturates.

Mechanism of action

The mechanism of action of mephenytoin is not definitely known, but extensive research strongly suggests that its main mechanism is to block frequency-, use- and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.

Synonyms and brand names

Synonyms

• Mephentoin
• Methyl Hydantoin
• Methylphenetoin

Brand Names

• Epiazin®
• Gerot-Epilan®
• Insulton®
• Mesdontoin®
• Mesontoin®
• Methoin®
• Metydan®
• Phenantoin®
• Sacerno®
• Sedantional®
• Sedantoin®
• Sedantoinal®
• Triantoin®

External links

The most up-to-date information about Mephenytoin and other drugs can be found at the following sites.

• Mephenytoin - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
• Mephenytoin - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
• Mephenytoin - Detailed information from DrugBank.