Transfusion reaction

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Revision as of 18:57, 6 November 2008 by imported>Robert Badgett (→‎Classification)
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A classification has been proposed by the American Association of Blood Banks (AABB).[1] In addition, the classification below is based on ICD9.

Immunologic

Febrile, nonhemolytic transfusion reaction (FNHTR)

This is a minor, acute reaction suggested by negative a Coombs' test, no free hemoglobin in the plasma, and no hemoglobin in the urine.

ABO incompatibility reaction

ICD9: 999.6

This reaction usually causes acute hemolysis.

Rh incompatibility reaction

ICD9: 999.7

This reaction usually causes delayed hemolysis.

Transfusion related acute lung injury (TRALI)

ICD9: 518.7

This is an acute reaction.

Nonimmunologic

Chemical reactions

  • Hemosiderosis
  • Hypocalcemia from citrate toxicity
  • Hyperkalemia
  • Metabolic alkalosis and hypokalemia due to citrate

Transmission of infection

Other reactions

  • Hypothermia
  • Circulatory overload
  • Hypotension associated with leukoreduced blood
  • Transfusion-related acute lung injury (pulmonary leukoagglutinin reaction) (TRALI)

References

  1. Sanders RP, Geiger TL, Heddle N, Pui CH, Howard SC (April 2007). "A revised classification scheme for acute transfusion reactions". Transfusion 47 (4): 621–8. DOI:10.1111/j.1537-2995.2007.01163.x. PMID 17381620. Research Blogging.