Anticoagulation

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Adverse effects

Patients aged 80 years or more may be especially susceptible to bleeding complications with a rate of 13 bleeds per 100 person-years.

Patients with cancer are more likely to have bleeding complications, especially if they have Stage 3 or 4 cancer. Regardless of the extent of cancer, the risk of bleeding was less than the risk of recurrent embolism and thromboembolism:

Rates of major bleeding and recurrent embolism and thromboembolism (VTE)

		No cancer	Stage I or II cancer	Stage III cancer	Stage IV cancer
Major bleeding	Events per 100 patient-years	8.6	3.4	19.1	42.8
	Hazard ratio	1	0.5	2.15	4.8
Recurrent VTE	Events per 100 patient-years	12.8	14.5	44.1	54.1
	Hazard ratio	1	1.9	5.3	4.6
Adapted from Table 3 of Prandoni et al.

See also

• Anticoagulant

External links

The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence-Based Guidelines