Hypericum
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In complementary and alternative medicine, hypericum, also called St John's wort may have medicinal purposes.
Pharmacology
A component of hypericum, hyperforin, may act as a serotonin uptake inhibitor.[1]
Clinical purposes
Hypericum may help treat mild depression.[2]
One randomized controlled trial found no benefit[3], whereas a subsequent trial using a higher dose of hypericum (900 mg/day hypericum extract three times a day) found benefit[4].
References
- ↑ Schulte-Löbbert S, Holoubek G, Müller WE, Schubert-Zsilavecz M, Wurglics M (2004). "Comparison of the synaptosomal uptake inhibition of serotonin by St John's wort products.". J Pharm Pharmacol 56 (6): 813-8. DOI:10.1211/0022357023493. PMID 15231048. Research Blogging.
- ↑ Geddes J, Butler R, Hatcher S, Cipriani A, Price J, Carney S et al. (2006). "Depression in adults.". Clin Evid (15): 1366-406. PMID 16973054. [e]
- ↑ Hypericum Depression Trial Study Group (2002). "Effect of Hypericum perforatum (St John's wort) in major depressive disorder: a randomized controlled trial.". JAMA 287 (14): 1807-14. PMID 11939866. [e] Review in: Evid Based Ment Health. 2002 Nov;5(4):111
- ↑ Szegedi A, Kohnen R, Dienel A, Kieser M (2005). "Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St John's wort): randomised controlled double blind non-inferiority trial versus paroxetine.". BMJ 330 (7490): 503. DOI:10.1136/bmj.38356.655266.82. PMID 15708844. PMC PMC552808. Research Blogging. Review in: Evid Based Ment Health. 2005 Nov;8(4):107