File:CO2-O2-fMRI-all.png
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Summary
| Title / Description
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Functional magnetic resonance imaging of the human brain during gas challenges. Instead of normal air, the participants inhaled either pure oxygen (hyperoxia condition), or 95% oxygen and 5% carbon dioxide (hypercapnic hyperoxia). Yellow (hyperoxia) and green (hypercapnic hyperoxia) overlays of regions of significant signal response in 14 children at any of five time successive periods during the challenges. Multiple brain regions responded to hyperoxia, but the addition of 5% O2 by CO2 greatly reduced most responses. Statistical threshold p = 0.05, false discovery rate correction. Abbreviations of anatomical locations: CC, cerebellum; DM, dorsal midbrain; DMT, dorsal medial thalamus; Hypo, hypothalamus; LAI/RAI, left/right anterior insula; LAP/RAP, left/right posterior insula; LCN/RCN, left/right caudate nucleus; LG, lingual gyrus; LHipp/RHipp, left/right hippocampus; LI/RI, left/right insula; PLT, posterior lateral thalamus; VLT, ventral lateral thalamus. Distances from the anterior commissure and orientation, based on the standard Montreal Neurological Institute space, are (A) 5 mm superior, (B) 5 mm left, (C) 27 mm right, and (D) 19 mm posterior. Distance increases from left-to-right for sagittal (side) views, posterior-to-anterior for coronal views, and inferior to superior for axial (transverse) views. The background image is a high-resolution scan from a single participant (normalized to Montreal Neurological Institute space). |
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| Author(s)
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Macey et al., 2007 |
| Copyright holder
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Macey et al., 2007 See below for license/re-use information. |
| Source
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Fig. 1 from Macey PM, Woo MA, Harper RM (2007). "Hyperoxic brain effects are normalized by addition of CO2". PLoS Med 4 (5): e173. DOI:10.1371/journal.pmed.0040173. PMID 17518514. PMC PMC1872042. Research Blogging. [e] |
| Date created
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June 26, 2006 |
| Country of first publication
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United States |
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| current | 18:52, 11 March 2022 | | 3,600 × 3,271 (2.53 MB) | Maintenance script (talk | contribs) | == Summary == Importing file |
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