Amanita virosa

Destroying Angel
	;
Scientific classification
Kingdom:	Fungi;
Division:	Basidiomycota;
Class:	Agaricomycetes;
Subclass:	Hymenomycetes;
Order:	Agaricales;
Family:	Amanitaceae;
Genus:	Amanita;
Species:	A. virosa;
Binomial name
	Amanita virosa;

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Classification and naming

Amanita virosa or the European destroying angel is one of a group of deadly pure white mushroom species known as a group as the destroying angels or the death angels. Amanita virosa is one of the most poisonous of all known toadstools. It belongs to the fungi kingdom; a poisonous basidiomycete fungus, one of many in the genus Amanita.

Amanita virosa was first collected and described by Elias Magnus Fries a Swedish mycologist and botanist.

Description

Amanita virosa is pure white in appearance with gills which are usually not attached to the stalk. The cap of the Destroying Angel is 2¼ to 6 inches wide. In young specimens, a white, membranous partial veil tissue extends from the edge of the cap to the upper stalk, covering the gills and later remaining attached to and draping from the upper stalk. The stalk is white and up to 8 inches long or tall, with a small, rounded bulb at the base; the bulb is enclosed by a sac-like volva. The base of the stalk and the volva are often buried in the soil. All parts of the Destroying Angel are white and turn bright yellow with the use of potassium hydroxide (KOH).

Young specimens of A. virosa are sometimes mistaken for puffballs or other non poisonous mushrooms and are picked and eaten.

(CC) Photo: William Rafti of the William Rafti Institute
Young specimens of A. virosa are sometimes mistaken for puffballs or other non poisonous mushrooms and are picked and eaten.

Distribution and habitat

A. virosa is found in late summer and autumn under broad leaved trees in mixed woodland, especially in association with beech, on mossy ground. All Amanita species form symbiotic relationships with the roots of certain trees.

Toxicity

Amanita virosa is highly toxic, and has been responsible for severe mushroom poisonings. Consumption is a medical emergency leading to necessary hospitalization. Although it closely resembles edible field mushrooms and puffballs, the Destroying Angel is one of the most poisonous of all known toadstools, containing amatoxins and phallotoxins that cause severe and usually fatal, liver and kidney damage.

The poison in the death angel is a relatively small protein made up of eight amino acids, a cyclopeptide called alpha-amanitin. Alpha-amanitin works by attacking RNA polymerase in the liver. The liver is mainly affected, since it is the first organ which is encountered after absorption in the gastrointestinal tract. The poison ultimately affects the central nervous system and the kidneys.

The first symptoms of poisoning are vomiting, persistent diarrhea, and severe stomach pains; the onset of symptoms normally occurs some eight to ten hours or as long as twenty-four hours after consumption. After this there may be a period of seeming improvement before the second effect of the poisoning occurs; this is deterioration in both liver and kidney functions. These will or may show up as a yellowing or discoloration of the whites of the eyes and skin, and discoloration of the urine.

Death usually takes place within a week to ten days from ingestion, progressing through a comatose stage to renal failure, liver failure, hepatic coma, respiratory failure and death.

Those who recover are at risk of permanent liver damage. Diagnosis is generally very difficult, and is established by observation of the clinical symptoms as well as the presence of amanitin in the urine. Urine screening is generally the most useful within 48 hours of mushroom consumption.

Treatment

Treatment for the poison is mainly supportive but it includes various drugs to counter the amatoxins, including intravenous penicillin and cephalosporin derivatives. The most reliable method to treat amanitin poisoning is through having the stomach pumped immediately after ingestion of the mushroom. However, by the time symptoms start it is in general too late for this to be a valid option.

There is no known antidote, though at the present time in case of greater ingestion, treatment can extend to kidney dialysis and/or liver transplant. In victims that develop liver failure, a liver transplant is often the only option to prevent death. Liver transplants have become the best option in amatoxin poisoning. This is a difficult issue, however, as transplants may also cause significant complications; including death and the requirement of long-term immunosuppression to maintain the transplant.

There has been a re-evaluation of decisive factors such as the onset of symptoms etc, for deciding at what point a liver transplant becomes necessary for survival. Some evidence suggests that, although survival rates have become better with modern medical procedures, in patients with moderate to severe poisoning up to half of those who did recover suffered permanent liver damage. However, follow up studies have shown that most victims recover totally without any serious symptoms if treated within 36 hours of mushroom ingestion.

(CC) Photo: Miika Silfverberg
European Destroying Angel (Amanita virosa) While some animals can eat this toadstool without harm, to humans it is one of the most toxic of all known fungi. No antidote is known and poisonings are often fatal.