Rickettsia rickettsii

Rickettsia rickettsii is the pathogen of Rocky Mountain spotted fever. Its epidemic potential caused it to be listed as a human threat in the Select Agent Program.

Life cycle

All rickettsial diseases are zoonoses; the animal host depends on which tick vector feeds on blood from the host in either the larval, nymphal, or adult stage. After an immature tick develops into the next stage, R. rickettsii may be transmitted to a second host during the feeding process. Furthermore, male ticks may transfer R. rickettsii to female ticks through body fluids or spermatozoa during the mating process. Once infected, a tick can carry the pathogen for life; it does not harm the tick. A female tick can also transmit R. rickettsii to her eggs in a process called transovarial transmission.

Not all rickettsiae can transmit through generations of arthropods as does this organism. In the U.S., the major vectors are the American dog tick (Dermacentor variabilis) and the Rocky Mountain wood tick (Dermacentor andersoni). Other ticks appear to be involved in natural transmission in Central and South America.

American dog ticks, the most common vector, sare widely distributed east of the Rocky Mountains and also occurs in limited areas on the Pacific Coast. Dogs and medium-sized mammals are the preferred hosts of adult D. variabilis, although it feeds readily on other large mammals, including humans.

Rocky Mountain wood ticks are found in the Rocky Mountain states and in southwestern Canada. The life cycle of this tick may require up to 2 to 3 years for completion. Adult ticks feed primarily on large mammals. Larvae and nymphs feed on small rodents.