Indinavir
Indinavir, also called indinavir sulfate or Compound J and sold under the trade name Crixivan®, is a protease inhibitor used to treat HIV/AIDS. The HIV-1 protease in required to cleave the viral gag-pol polyprotein into individual functional proteins to make an infectious mature viral particle. Indinavir binds to the HIV-1 protease, inhibiting its function and stopping the production of infectious viral particles. Protease inhibitors are usually used with two or more other anti-HIV medications. Symptoms of overdose include heart attack and chest pain.
Its IUPAC chemical name is (2S)-N-tert-butyl-1-[(2S,4R)-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxo-4-(phenylmethyl)pentyl]-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide and it has chemical formula C36H47N5O4.
External Links
Indinavir - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine). Drug Bank at http://www.drugbank.ca/cgi-bin/getCard.cgi?CARD=DB00224.txt