Omeprazole
Omeprazole is a pharmaceutical molecule that selectively inhibits the proton pump, specifically H+, K+-ATPase, a membrane-bound exchange pump, pumping H+in exchange for K+ across the membrane. It suppresses acidification of the fluid in the cavity (lumen) of the stomach and has medicinal value in the treatment of disorders caused or aggravated by the acidity of the fluid in the stomach (gastric) lumen.
History
Prilosec delayed release brand of omeprazole was approved for AstraZeneca by the Food and Drug Administration in the United States with a New Drug Application (NDA) in 1989.[1] A generic version with a AB Therapeutic Equivalence Code was approved with a Abbreviated New Drug Application (ANDA) in 2008.[2] In 4/2008, a delayed release version became an authorized generic.[3]
Pharmacology
Administration
Distribution
Metabolism
Excretion
Toxicity
Drug toxicity includes
External links
The most up-to-date information about Omeprazole and other drugs can be found at the following sites.
- Omeprazole - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Omeprazole - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Omeprazole - Detailed information from DrugBank.
References
- ↑ Anonymous. Drugs@FDA for FDA Application No. 019810. U S Food and Drug Administration
- ↑ Anonymous. Drugs@FDA for FDA Application No. 075347. U S Food and Drug Administration
- ↑ FDA Listing of Authorized Generics as of June 27, 2011