CZ:Featured article/Current

Hypercholesterolemia

Hypercholesterolemia is "a condition with abnormally high levels of cholesterol in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population."^[1] It should be differentiated from dyslipidemia, where the total cholesterol may not be abnormally high, but the ratios of lipid components are in an unhealthy range.

Prognostication

Non-HDL cholesterol and apolipoprotein B levels may better predict subsequent vascular disease thatn LDL-C levels.^[2]According to the Friedewald formula, non-HDL cholesterol is LDL-cholesterol LDL-C and VLDL-C.^[3] If LDL-C levels are used as goals of therapy:^[4]

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notes
↑ Anonymous. Hypercholesterolemia. National Library of Medicine. Retrieved on 2008-01-18. ↑ Boekholdt SM, Arsenault BJ, Mora S, Pedersen TR, LaRosa JC, Nestel PJ et al. (2012). "Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis.". JAMA 307 (12): 1302-9. DOI:10.1001/jama.2012.366. PMID 22453571. Research Blogging. ↑ Friedewald WT, Levy RI, Fredrickson DS (1972). "Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.". Clin Chem 18 (6): 499-502. PMID 4337382. ^[e] ↑ National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2002). "Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report.". Circulation 106 (25): 3143-421. PMID 12485966. ^[e]

[title-1] Anonymous. Hypercholesterolemia. National Library of Medicine. Retrieved on 2008-01-18.

[pmid22453571-2] Boekholdt SM, Arsenault BJ, Mora S, Pedersen TR, LaRosa JC, Nestel PJ et al. (2012). "Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis.". JAMA 307 (12): 1302-9. DOI:10.1001/jama.2012.366. PMID 22453571. Research Blogging.

[pmid4337382-3] Friedewald WT, Levy RI, Fredrickson DS (1972). "Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.". Clin Chem 18 (6): 499-502. PMID 4337382. ^[e]

[pmid12485966-4] National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2002). "Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report.". Circulation 106 (25): 3143-421. PMID 12485966. ^[e]

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CZ:Featured article/Current

Hypercholesterolemia

Prognostication

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