Colchicine
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In pharmacology, colchicine is a "major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (period disease)."[1]
Dosage
Acute gout attack
Initially 1 to 1.2 milligrams, then one of the following until symptoms better or gastrointestinal drug toxicity (stomach pain, vomiting or diarrhea) occur:[2]
- 0.5 to 0.6 milligram every hour
- 1 to 1.2 milligrams every two hours. 0.5 mg every 2 hours has been used, but still causes consistent toxicity[3]
- 0.5 to 0.6 milligram every 2 to 3 hours
The maximum dose per attack is 4 to 8 milligrams total.
References
- ↑ Anonymous (2024), Colchicine (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Colchicine. In: DRUGDEX® System (Internet database). Greenwood Village, Colo: Thomson Healthcare. Updated periodically.
- ↑ Ahern MJ, Reid C, Gordon TP, McCredie M, Brooks PM, Jones M (June 1987). "Does colchicine work? The results of the first controlled study in acute gout". Aust N Z J Med 17 (3): 301–4. DOI:10.1111/j.1445-5994.1987.tb01232.x. PMID 3314832. Research Blogging. Summary at Bandolier
External references
The most up-to-date information about Colchicine and other drugs can be found at the following sites.
- Colchicine - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Colchicine - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Colchicine - Detailed information from DrugBank.