Transfusion reaction

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Revision as of 18:57, 6 November 2008 by imported>Robert Badgett (→‎Classification)
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A classification has been proposed by the American Association of Blood Banks (AABB).[1] In addition, the classification below is based on ICD9.

Immunologic

Febrile, nonhemolytic transfusion reaction (FNHTR)

This is a minor, acute reaction suggested by negative a Coombs' test, no free hemoglobin in the plasma, and no hemoglobin in the urine.

ABO incompatibility reaction

ICD9: 999.6

This reaction usually causes acute hemolysis.

Rh incompatibility reaction

ICD9: 999.7

This reaction usually causes delayed hemolysis.

Transfusion related acute lung injury (TRALI)

ICD9: 518.7

This is an acute reaction.

Nonimmunologic

Chemical reactions

  • Hemosiderosis
  • Hypocalcemia from citrate toxicity
  • Hyperkalemia
  • Metabolic alkalosis and hypokalemia due to citrate

Transmission of infection

Other reactions

  • Hypothermia
  • Circulatory overload
  • Hypotension associated with leukoreduced blood
  • Transfusion-related acute lung injury (pulmonary leukoagglutinin reaction) (TRALI)

References

  1. ↑ Sanders RP, Geiger TL, Heddle N, Pui CH, Howard SC (April 2007). "A revised classification scheme for acute transfusion reactions". Transfusion 47 (4): 621–8. DOI:10.1111/j.1537-2995.2007.01163.x. PMID 17381620. Research Blogging.
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