Delavirdine

delavirdine
IUPAC name: see chemistry section Synonyms: SPP Formula: C22H28N6O3S
Uses:	HIV
Properties:	Reverse Transcriptase inhibitor
Hazards:	see drug interactions
Mass (g/mol): CAS #: 456.5611 136817-59-9

Delavirdine (DLV), also called SPP, is an antiviral drug that is a non-nucleoside, reverse transcriptase inhibitor (nNRTI) specific for HIV-1. It binds directly to reverse transcriptase catalytic site and blocks the DNA polymerase activity. HIV-2 RT and eukaryotic (human, for example) DNA polymerases are not effected by this drug. Rashes are the major side effect of delavirdine toxicity, and they should be reported to the attending physician. Rashes typically are resolved in two weeks or less, but patients with severe rash or rash accompanied by fever, blistering, oral lesions, conjunctivitis, swelling, muscle or joint aches should discontinue medication and consult a physician.