Allergic rhinitis
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Allergic rhinitis, also called seasonal allergic rhinitis is defined as "rhinitis that occurs at the same time every year. It is characterized by acute conjunctivitis with lacrimation and itching, and regarded as an allergic condition triggered by specific allergens."[1]
Cause / etiology
Allergic rhinitis may be associated with bronchial hyperreactivity.[2]
Diagnosis
Treatment
Clinical practice guidelines by written by authors with conflict of interests address the treatment.[3]
Among alpha adrenergic receptor agonists, pseudoephedrine may be better than phenylephrine in the improvement of nasal congestion.[4]
The most effective treatment is intranasal corticosteroids according to systematic reviews of randomized controlled trials.[5][6]
Combination treatment
Regarding adding histamine H1 antagonists to intranasal corticosteroids:
- Intranasal histamine H1 antagonists may help. Azelastine nasal spray and fluticasone nasal spray in combination may be more effective than either used alone according to a randomized controlled trial that was not registered and had conflict of interest.[7]
- However oral histamine H1 antagonists may not help.[8][9][10][11][12]
References
- ↑ National Library of Medicine. Allergic rhinitis. Retrieved on 2007-11-08.
- ↑ Shaaban R, Zureik M, Soussan D, et al (2007). "Allergic rhinitis and onset of bronchial hyperresponsiveness: a population-based study". Am. J. Respir. Crit. Care Med. 176 (7): 659–66. DOI:10.1164/rccm.200703-427OC. PMID 17615387. Research Blogging.
- ↑ Wallace DV, Dykewicz MS, Bernstein DI, et al (August 2008). "The diagnosis and management of rhinitis: an updated practice parameter". J. Allergy Clin. Immunol. 122 (2 Suppl): S1–84. DOI:10.1016/j.jaci.2008.06.003. PMID 18662584. Research Blogging.
- ↑ Horak F, Zieglmayer P, Zieglmayer R, et al (February 2009). "A placebo-controlled study of the nasal decongestant effect of phenylephrine and pseudoephedrine in the Vienna Challenge Chamber". Ann. Allergy Asthma Immunol. 102 (2): 116–20. PMID 19230461. [e]
- ↑ Benninger M, Farrar JR, Blaiss M, Chipps B, Ferguson B, Krouse J et al. (2010). "Evaluating approved medications to treat allergic rhinitis in the United States: an evidence-based review of efficacy for nasal symptoms by class.". Ann Allergy Asthma Immunol 104 (1): 13-29. PMID 20143641.
- ↑ Weiner JM, Abramson MJ, Puy RM (1998). "Intranasal corticosteroids versus oral H1 receptor antagonists in allergic rhinitis: systematic review of randomised controlled trials.". BMJ 317 (7173): 1624-9. PMID 9848901. PMC PMC28740.
- ↑ Ratner PH, Hampel F, Van Bavel J, et al (2008). "Combination therapy with azelastine hydrochloride nasal spray and fluticasone propionate nasal spray in the treatment of patients with seasonal allergic rhinitis". Ann. Allergy Asthma Immunol. 100 (1): 74–81. DOI:10.1016/S1081-1206(10)60408-5. PMID 18254486. Research Blogging.
- ↑ Barnes ML, Ward JH, Fardon TC, Lipworth BJ (2006). "Effects of levocetirizine as add-on therapy to fluticasone in seasonal allergic rhinitis.". Clin Exp Allergy 36 (5): 676-84. DOI:10.1111/j.1365-2222.2006.02478.x. PMID 16650054. Research Blogging.
- ↑ Ratner PH, van Bavel JH, Martin BG, Hampel FC, Howland WC, Rogenes PR et al. (1998). "A comparison of the efficacy of fluticasone propionate aqueous nasal spray and loratadine, alone and in combination, for the treatment of seasonal allergic rhinitis.". J Fam Pract 47 (2): 118-25. PMID 9722799.
- ↑ Simpson RJ (1994). "Budesonide and terfenadine, separately and in combination, in the treatment of hay fever.". Ann Allergy 73 (6): 497-502. PMID 7998664.
- ↑ Di Lorenzo G, Pacor ML, Pellitteri ME, Morici G, Di Gregoli A, Lo Bianco C et al. (2004). "Randomized placebo-controlled trial comparing fluticasone aqueous nasal spray in mono-therapy, fluticasone plus cetirizine, fluticasone plus montelukast and cetirizine plus montelukast for seasonal allergic rhinitis.". Clin Exp Allergy 34 (2): 259-67. PMID 14987306.
- ↑ Anolik R, Mometasone Furoate Nasal Spray With Loratadine Study Group (2008). "Clinical benefits of combination treatment with mometasone furoate nasal spray and loratadine vs monotherapy with mometasone furoate in the treatment of seasonal allergic rhinitis.". Ann Allergy Asthma Immunol 100 (3): 264-71. DOI:10.1016/S1081-1206(10)60452-8. PMID 18426147. Research Blogging.
External links
- Allergic rhinitis - Information for patients from MedlinePlus (United States National Library of Medicine).