Mirtazapine: Difference between revisions
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'''Mirtazapine''' is a [[second-generation antidepressant]] agent. | '''Mirtazapine''' is a [[second-generation antidepressant]] agent. Mirtazapine is also classified as a [[tricyclic antidepressant]] by the [[National Library of Medicine]] in the [[United States]].<ref>{{MeSH|Mirtazapine }}</ref> | ||
==History== | ==History== | ||
Revision as of 10:12, 27 December 2011
Mirtazapine is a second-generation antidepressant agent. Mirtazapine is also classified as a tricyclic antidepressant by the National Library of Medicine in the United States.[1]
History
Remeron brand of mirtazapine was approved for Organon USA by the Food and Drug Administration in the United States with a New Drug Application (NDA) in 1996.[2] A generic version with a AB Therapeutic Equivalence Code was approved for Glenmark Generics with a Abbreviated New Drug Application (ANDA) in 2004.[3]
Effectiveness
"The clinical response of our patients underscores the usefulness of mirtazapine in the treatment of the comorbid symptoms of weight loss, insomnia, and anxiety". [4]
Pharmacology
Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA).[5]
Administration
Distribution
Metabolism
Excretion
Toxicity
Drug toxicity is similar to tricyclic antidepressants. Amitriptyline, mirtazapine, and paroxetine may case more weight gain than other antidepressants according to a meta-analysis.[6]
Compared to other antidepressants, a second meta-analysis found that mirtazapine was "more likely to cause weight gain or increased appetite and somnolence than SSRIs but less likely to cause nausea or vomiting and sexual dysfunction."[5]
External links
The most up-to-date information about Mirtazapine and other drugs can be found at the following sites.
- Mirtazapine - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Mirtazapine - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Mirtazapine - Detailed information from DrugBank.
References
- ↑ Anonymous (2024), Mirtazapine (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Anonymous. Drugs@FDA for FDA Application No. 020415. U S Food and Drug Administration
- ↑ Anonymous. Drugs@FDA for FDA Application No. 076119. U S Food and Drug Administration
- ↑ Raji MA, Brady SR (2001). "Mirtazapine for treatment of depression and comorbidities in Alzheimer disease.". Ann Pharmacother 35 (9): 1024-7. PMID 11573849. [e]
- ↑ 5.0 5.1 Watanabe N, Omori IM, Nakagawa A, Cipriani A, Barbui C, Churchill R et al. (2011). "Mirtazapine versus other antidepressive agents for depression.". Cochrane Database Syst Rev 12: CD006528. DOI:10.1002/14651858.CD006528.pub2. PMID 22161405. Research Blogging.
- ↑ Serretti A, Mandelli L (2010). "Antidepressants and body weight: a comprehensive review and meta-analysis.". J Clin Psychiatry 71 (10): 1259-72. DOI:10.4088/JCP.09r05346blu. PMID 21062615. Research Blogging.