Lipostatic hypothesis

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In 1953, Kennedy proposed what became known as the lipostatic hyothesis. Specifically, he postulated the existence, in the hypothalamus, of a centre that was sensitive to the concentration of metabolites in the circulation, which prevented "an overall surplus of energy intake over expenditure."

References

Zhang Y & Scarpace PJ (2006) The role of leptin in leptin resistance and obesity. Physiol Behav. 88, 249-256.