Paraneoplastic cerebellar degeneration: Difference between revisions
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imported>Robert Badgett (New page: In medicine, '''paraneoplastic cerebellar degeneration''' is a type of nervous system paraneoplastic syndrome and is a "cerebellar degeneration associated with a remote neoplasm. C...) |
imported>Howard C. Berkowitz No edit summary |
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In [[neurology]] and [[oncology]], '''paraneoplastic cerebellar degeneration''' is a type of [[nervous system paraneoplastic syndrome]] and is a "cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and [[gait ataxia]]; [[dysarthria]]; and [[nystagmus, pathologic]]. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals."<ref>{{MeSH}}</ref><ref name="pmid17287482">{{cite journal| author=Dalmau J, Gonzalez RG, Lerwill MF| title=Case records of the Massachusetts General Hospital. Case 4-2007. A 56-year-old woman with rapidly progressive vertigo and ataxia. | journal=N Engl J Med | year= 2007 | volume= 356 | issue= 6 | pages= 612-20 | pmid=17287482 | url=http://content.nejm.org/cgi/content/full/356/6/612 | doi=10.1056/NEJMcpc069035 }} </ref> | |||
==Treatment== | ==Treatment== | ||
Latest revision as of 18:40, 22 August 2010
In neurology and oncology, paraneoplastic cerebellar degeneration is a type of nervous system paraneoplastic syndrome and is a "cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and gait ataxia; dysarthria; and nystagmus, pathologic. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals."[1][2]
Treatment
Intravenous immunoglobulins
References
- ↑ Anonymous (2024), Paraneoplastic cerebellar degeneration (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Dalmau J, Gonzalez RG, Lerwill MF (2007). "Case records of the Massachusetts General Hospital. Case 4-2007. A 56-year-old woman with rapidly progressive vertigo and ataxia.". N Engl J Med 356 (6): 612-20. DOI:10.1056/NEJMcpc069035. PMID 17287482. Research Blogging.