Total iron binding capacity: Difference between revisions
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'''Total iron binding capacity (TIBC)''' is indirect measurement of [[transferrin]] | '''Total iron binding capacity (TIBC)''' is indirect measurement of [[transferrin#roles and receptors|transferrin receptor]]s in blood. It is one one of the tests used in the differential diagnosis of [[anemia]], the other major biochemical measurements being [[serum iron]] (SI), and serum [[ferritin]]. While the test is in widespread use, direct transferrin receptor measurement tests are becoming available for clinical practice. | ||
==Method== | ==Method== | ||
TIBC is calculated as the sum of [[unsaturated iron binding capacity]](UIBC) and [serum iron]]. Unsaturated iron binding capacity is directly measured by adding a known amount of iron to serum, and measuring the amount of iron that does not bind to transferrin receptors. | TIBC is calculated as the sum of [[unsaturated iron binding capacity]] (UIBC) and [[serum iron]]. Unsaturated iron binding capacity is directly measured by adding a known amount of iron to serum, and measuring the amount of iron that does not bind to transferrin receptors. | ||
Revision as of 15:59, 3 January 2010
Total iron binding capacity (TIBC) is indirect measurement of transferrin receptors in blood. It is one one of the tests used in the differential diagnosis of anemia, the other major biochemical measurements being serum iron (SI), and serum ferritin. While the test is in widespread use, direct transferrin receptor measurement tests are becoming available for clinical practice.
Method
TIBC is calculated as the sum of unsaturated iron binding capacity (UIBC) and serum iron. Unsaturated iron binding capacity is directly measured by adding a known amount of iron to serum, and measuring the amount of iron that does not bind to transferrin receptors.