Natriuretic peptide: Difference between revisions
Jump to navigation
Jump to search
imported>Tom Morris No edit summary |
imported>Robert Badgett No edit summary |
||
| Line 2: | Line 2: | ||
In [[physiology]], '''natriuretic peptides''' are "Peptides that regulate the water-electrolyte balance in the body, also known as natriuretic peptide hormones. Several have been sequenced ([[atrial natriuretic factor]]; [[brain natriuretic peptide]]; [[c-type natriuretic peptide]])."<ref>{{MeSH}}</ref> In addition, N-terminal pro-B-type natriuretic peptide (NT-proBNP) is an inactive peptide that is co-secreted with [[brain natriuretic peptide]].<ref name="pmid19815122">{{cite journal| author=Steinhart B, Thorpe KE, Bayoumi AM, Moe G, Januzzi JL, Mazer CD| title=Improving the diagnosis of acute heart failure using a validated prediction model. | journal=J Am Coll Cardiol | year= 2009 | volume= 54 | issue= 16 | pages= 1515-21 | pmid=19815122 | In [[physiology]], '''natriuretic peptides''' are "Peptides that regulate the water-electrolyte balance in the body, also known as natriuretic peptide hormones. Several have been sequenced ([[atrial natriuretic factor]]; [[brain natriuretic peptide]]; [[c-type natriuretic peptide]])."<ref>{{MeSH}}</ref> In addition, N-terminal pro-B-type natriuretic peptide (NT-proBNP) is an inactive peptide that is co-secreted with [[brain natriuretic peptide]].<ref name="pmid19815122">{{cite journal| author=Steinhart B, Thorpe KE, Bayoumi AM, Moe G, Januzzi JL, Mazer CD| title=Improving the diagnosis of acute heart failure using a validated prediction model. | journal=J Am Coll Cardiol | year= 2009 | volume= 54 | issue= 16 | pages= 1515-21 | pmid=19815122 | ||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=19815122 | doi=10.1016/j.jacc.2009.05.065 }} | | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=19815122 | doi=10.1016/j.jacc.2009.05.065 }}</ref> | ||
[[Brain natriuretic peptide]] and N-terminal pro-B-type natriuretic peptide are used as [[diagnostic test]]s to detect [[heart failure]].<ref name="pmid19586584">{{cite journal| author=Mant J, Doust J, Roalfe A, Barton P, Cowie MR, Glasziou P et al.| title=Systematic review and individual patient data meta-analysis of diagnosis of heart failure, with modelling of implications of different diagnostic strategies in primary care. | journal=Health Technol Assess | year= 2009 | volume= 13 | issue= 32 | pages= 1-207, iii | pmid=19586584 | [[Brain natriuretic peptide]] and N-terminal pro-B-type natriuretic peptide are used as [[diagnostic test]]s to detect [[heart failure]].<ref name="pmid19586584">{{cite journal| author=Mant J, Doust J, Roalfe A, Barton P, Cowie MR, Glasziou P et al.| title=Systematic review and individual patient data meta-analysis of diagnosis of heart failure, with modelling of implications of different diagnostic strategies in primary care. | journal=Health Technol Assess | year= 2009 | volume= 13 | issue= 32 | pages= 1-207, iii | pmid=19586584 | ||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=19586584 | doi=10.3310/hta13320 }} | | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=19586584 | doi=10.3310/hta13320 }}</ref><ref name="pmid17764210">{{cite journal| author=Balion C, Santaguida PL, Hill S, Worster A, McQueen M, Oremus M et al.| title=Testing for BNP and NT-proBNP in the diagnosis and prognosis of heart failure. | journal=Evid Rep Technol Assess (Full Rep) | year= 2006 | volume= | issue= 142 | pages= 1-147 | pmid=17764210 | ||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=17764210 }} | | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=17764210 }} </ref> Both have a [[sensitivity and specificity|sensitivity]] over 90% but have a [[sensitivity and specificity|specificity]] of less than 70%.<ref name="pmid19586584"/><ref name="pmid17764210"/> | ||
BNP levels do not elevate much in right heart failure unless the right heart pressure is elevated.<ref name="pmid9426041">{{cite journal| author=Nagaya N, Nishikimi T, Okano Y, Uematsu M, Satoh T, Kyotani S et al.| title=Plasma brain natriuretic peptide levels increase in proportion to the extent of right ventricular dysfunction in pulmonary hypertension. | journal=J Am Coll Cardiol | year= 1998 | volume= 31 | issue= 1 | pages= 202-8 | pmid=9426041 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9426041 }} </ref> | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Latest revision as of 12:33, 15 June 2012
In physiology, natriuretic peptides are "Peptides that regulate the water-electrolyte balance in the body, also known as natriuretic peptide hormones. Several have been sequenced (atrial natriuretic factor; brain natriuretic peptide; c-type natriuretic peptide)."[1] In addition, N-terminal pro-B-type natriuretic peptide (NT-proBNP) is an inactive peptide that is co-secreted with brain natriuretic peptide.[2]
Brain natriuretic peptide and N-terminal pro-B-type natriuretic peptide are used as diagnostic tests to detect heart failure.[3][4] Both have a sensitivity over 90% but have a specificity of less than 70%.[3][4]
BNP levels do not elevate much in right heart failure unless the right heart pressure is elevated.[5]
References
- ↑ Anonymous (2024), Natriuretic peptide (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Steinhart B, Thorpe KE, Bayoumi AM, Moe G, Januzzi JL, Mazer CD (2009). "Improving the diagnosis of acute heart failure using a validated prediction model.". J Am Coll Cardiol 54 (16): 1515-21. DOI:10.1016/j.jacc.2009.05.065. PMID 19815122. Research Blogging.
- ↑ 3.0 3.1 Mant J, Doust J, Roalfe A, Barton P, Cowie MR, Glasziou P et al. (2009). "Systematic review and individual patient data meta-analysis of diagnosis of heart failure, with modelling of implications of different diagnostic strategies in primary care.". Health Technol Assess 13 (32): 1-207, iii. DOI:10.3310/hta13320. PMID 19586584. Research Blogging.
- ↑ 4.0 4.1 Balion C, Santaguida PL, Hill S, Worster A, McQueen M, Oremus M et al. (2006). "Testing for BNP and NT-proBNP in the diagnosis and prognosis of heart failure.". Evid Rep Technol Assess (Full Rep) (142): 1-147. PMID 17764210.
- ↑ Nagaya N, Nishikimi T, Okano Y, Uematsu M, Satoh T, Kyotani S et al. (1998). "Plasma brain natriuretic peptide levels increase in proportion to the extent of right ventricular dysfunction in pulmonary hypertension.". J Am Coll Cardiol 31 (1): 202-8. PMID 9426041. [e]