Brain natriuretic peptide: Difference between revisions
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An elevated concentration of BNP in the circulation can detect [[heart failure]]:<ref name="pmid12124404">{{cite journal |author=Maisel AS, Krishnaswamy P, Nowak RM, ''et al'' |title=Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure |journal=N Engl J Med |volume=347 |pages=161–7 |year=2002 |month=July |pmid=12124404 |doi=10.1056/NEJMoa020233 |url=http://content.nejm.org/cgi/pmidlookup?view=short&pmid=12124404&promo=ONFLNS19 |issn=}}</ref> | An elevated concentration of BNP in the circulation can detect [[heart failure]]:<ref name="pmid12124404">{{cite journal |author=Maisel AS, Krishnaswamy P, Nowak RM, ''et al'' |title=Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure |journal=N Engl J Med |volume=347 |pages=161–7 |year=2002 |month=July |pmid=12124404 |doi=10.1056/NEJMoa020233 |url=http://content.nejm.org/cgi/pmidlookup?view=short&pmid=12124404&promo=ONFLNS19 |issn=}}</ref> | ||
==Test accuracy== | |||
{| class="wikitable" | {| class="wikitable" | ||
|+ Usig the BNP to detect heart failure<ref name="pmid12124404"/> | |+ Usig the BNP to detect heart failure<ref name="pmid12124404"/> | ||
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| BNP > 50 pg per milliliter|| 97%|| 62% | | BNP > 50 pg per milliliter|| 97%|| 62% | ||
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==Effect on clinical decision making== | |||
Providing physicians quick access to BNP results may<ref name="pmid14960741">{{cite journal |author=Mueller C, Scholer A, Laule-Kilian K, ''et al.'' |title=Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea |journal=N. Engl. J. Med. |volume=350 |issue=7 |pages=647–54 |year=2004 |month=February |pmid=14960741 |doi=10.1056/NEJMoa031681 |url=http://content.nejm.org/cgi/pmidlookup?view=short&pmid=14960741&promo=ONFLNS19 |issn=}}</ref> or may not<ref name="pmid19293069">{{cite journal |author=Schneider HG, Lam L, Lokuge A, ''et al.'' |title=B-type natriuretic peptide testing, clinical outcomes, and health services use in emergency department patients with dyspnea: a randomized trial |journal=Ann. Intern. Med. |volume=150 |issue=6 |pages=365–71 |year=2009 |month=March |pmid=19293069 |doi= |url=http://www.annals.org/cgi/pmidlookup?view=long&pmid=19293069 |issn=}}</ref> improve the emergency evaluation of [[dyspnea]]. | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 07:29, 26 May 2009
In medicine, brain natriuretic peptide (BNP) is a "peptide that is secreted by the brain and the heart atria, stored mainly in cardiac ventricular myocardium. It can cause natriuresis; diuresis; vasodilation; and inhibits secretion of renin and aldosterone. It improves heart function. It contains 32 amino acids."[1]
BNP is one member or a family of closely related peptides called "natriuretic peptides" because of their ability to stimulate sodium excretion (natriuresis). Natriuretic peptides are functional antagonists to the renin-angiotensin-aldosterone system. BNP was given its name because it was first discovered in the porcine brain. [2] However, confusingly, there appears to be relatively little BNP expressed in the brain compared to atrial natriuretic peptide [3]
An elevated concentration of BNP in the circulation can detect heart failure:[4]
Test accuracy
| Sensitivity | Specificity | |
|---|---|---|
| BNP > 100 pg per milliliter | 90% | 76% |
| BNP > 50 pg per milliliter | 97% | 62% |
Effect on clinical decision making
Providing physicians quick access to BNP results may[5] or may not[6] improve the emergency evaluation of dyspnea.
References
- ↑ Anonymous (2024), Brain natriuretic peptide (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Baxter GF (2004) The natriuretic peptides. Basic Res Cardiol 99:71-5. PMID 14963664
- ↑ Langub MC et al. (1995) Distribution of natriuretic peptide precursor mRNAs in the rat brain. J Comp Neurol 356:183-99. PMID 7629314
- ↑ 4.0 4.1 Maisel AS, Krishnaswamy P, Nowak RM, et al (July 2002). "Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure". N Engl J Med 347: 161–7. DOI:10.1056/NEJMoa020233. PMID 12124404. Research Blogging.
- ↑ Mueller C, Scholer A, Laule-Kilian K, et al. (February 2004). "Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea". N. Engl. J. Med. 350 (7): 647–54. DOI:10.1056/NEJMoa031681. PMID 14960741. Research Blogging.
- ↑ Schneider HG, Lam L, Lokuge A, et al. (March 2009). "B-type natriuretic peptide testing, clinical outcomes, and health services use in emergency department patients with dyspnea: a randomized trial". Ann. Intern. Med. 150 (6): 365–71. PMID 19293069. [e]