Valproic acid: Difference between revisions
imported>Howard C. Berkowitz (Uses in mood disorder and neurogenic pain; side effect of tremor) |
imported>David E. Volk No edit summary |
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{{Chem infobox | |||
|align=right | |||
|image=[[Image:Valproic acid.jpg|center|thumb|125px]] | |||
|width=125px | |||
|molname=valproic acid | |||
|synonyms=Abbott-44089; 2-Propylpentanoic acid; 2-Propylvaleric acid; di-n-dipropylacetic acid | |||
|molformula= C<sub>8</sub>H<sub>16</sub>O<sub>2</sub> | |||
|molmass= 144.2 | |||
|uses=anticonvulsant | |||
|properties=fatty acid derivative | |||
|hazards= | |||
|iupac= | |||
|casnumber= 99-66-1 | |||
}} | |||
[[Image:Valproic acid.jpg|right|thumb|350px|{{#ifexist:Template:Valproic acid.jpg/credit|{{Valproic acid.jpg/credit}}<br/>|}}Add image caption here.]] | |||
'''Valproic acid''' is a medication that is "a [[fatty acid]] with anticonvulsant properties used in the treatment of [[epilepsy]]; the sodium salt is used in treating [[mood disorders]]. It also is used for [[neurogenic pain]]. | '''Valproic acid''' is a medication that is "a [[fatty acid]] with anticonvulsant properties used in the treatment of [[epilepsy]]; the sodium salt is used in treating [[mood disorders]]. It also is used for [[neurogenic pain]]. | ||
The mechanisms of its therapeutic actions are not well understood. It may act by increasing [[gamma-aminobutyric acid]] levels in the [[brain]] or by altering the properties of voltage dependent sodium channels."<ref>{{MeSH}}</ref> | The mechanisms of its therapeutic actions are not well understood. It may act by increasing [[gamma-aminobutyric acid]] levels in the [[brain]] or by altering the properties of voltage dependent sodium channels."<ref>{{MeSH}}</ref> | ||
== Side effects == | == Side effects == | ||
Valproic acid causes [[carnitine]] deficiency. All patients under valproate therapy should have their carnitine status monitored. Since available tests are not reliable indicators of carnitine status in tissues, prophylactic carnitine therapy can be considered. Intravenous carnitine is markedly | Valproic acid causes [[carnitine]] deficiency. All patients under valproate therapy should have their carnitine status monitored. Since available tests are not reliable indicators of carnitine status in tissues, prophylactic carnitine therapy can be considered. Intravenous carnitine is markedly | ||
Revision as of 10:07, 29 June 2008
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| valproic acid | |||||||
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| Uses: | anticonvulsant | ||||||
| Properties: | fatty acid derivative | ||||||
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Valproic acid is a medication that is "a fatty acid with anticonvulsant properties used in the treatment of epilepsy; the sodium salt is used in treating mood disorders. It also is used for neurogenic pain.
The mechanisms of its therapeutic actions are not well understood. It may act by increasing gamma-aminobutyric acid levels in the brain or by altering the properties of voltage dependent sodium channels."[1]
Side effects
Valproic acid causes carnitine deficiency. All patients under valproate therapy should have their carnitine status monitored. Since available tests are not reliable indicators of carnitine status in tissues, prophylactic carnitine therapy can be considered. Intravenous carnitine is markedly superior to oral; oral acetylcarnitine may be advantageously used as well, if the underlying disorder allows it.
Benign hand tremor is not infrequent as a side effect, and can be suppressed, if there are no contraindications to their use, with beta-adrenergic antagonists.
External links
Valproic acid - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
References
- ↑ Anonymous (2024), Valproic acid (English). Medical Subject Headings. U.S. National Library of Medicine.