Sildenafil: Difference between revisions
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'''Sildenafil''', widely known as [[Viagra]]®, is a medication used to treat [[erectile dysfunction]]. It was the first commercialized ''selective'' [[phosphodiesterase]] type 5 ([[PDE-5]]) inhibitor and was immediately popular both for treating erectile dysfunction and for recreational use. Sildenafil works by binding to phosphodiesterase type-5 enzymes, competing with the natural ligand [[cyclic guanine monophosphate]] (cGMP), which is structurally similar to sildenafil. [[Vardenafil]], a newer and more potent PDE-5 inhibitor, is nearly identical to sildenafil, while [[tadalafil]] is considerably different in structure. | '''Sildenafil''', widely known as [[Viagra]]®, is a medication used to treat [[erectile dysfunction]]. It was the first commercialized ''selective'' [[phosphodiesterase]] type 5 ([[PDE-5]]) inhibitor and was immediately popular both for treating erectile dysfunction and for recreational use. Sildenafil works by binding to phosphodiesterase type-5 enzymes, competing with the natural ligand [[cyclic guanine monophosphate]] (cGMP), which is structurally similar to sildenafil. [[Vardenafil]], a newer and more potent PDE-5 inhibitor, is nearly identical to sildenafil, while [[tadalafil]] is considerably different in structure. | ||
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== References == | == References == | ||
{{cite journal|title=Molecular Biology and Pharmacology of PDE-5-Inhibitor Therapy for Erectile Dysfunction|author=J. D. Corbin and S. H. Sharron|journal=J. Androl.|volume=24|pages=S38-S41}} | {{cite journal|title=Molecular Biology and Pharmacology of PDE-5-Inhibitor Therapy for Erectile Dysfunction|author=J. D. Corbin and S. H. Sharron|journal=J. Androl.|volume=24|pages=S38-S41}} | ||
Revision as of 16:20, 21 June 2008
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| Uses: | Erectile Dysfunction | ||||||
| Properties: | PDE-5 inhibitor | ||||||
| Hazards: | cardiovascular risks | ||||||
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Sildenafil, widely known as Viagra®, is a medication used to treat erectile dysfunction. It was the first commercialized selective phosphodiesterase type 5 (PDE-5) inhibitor and was immediately popular both for treating erectile dysfunction and for recreational use. Sildenafil works by binding to phosphodiesterase type-5 enzymes, competing with the natural ligand cyclic guanine monophosphate (cGMP), which is structurally similar to sildenafil. Vardenafil, a newer and more potent PDE-5 inhibitor, is nearly identical to sildenafil, while tadalafil is considerably different in structure.
Sildenafil - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine). Template:MedMaster Template:DrugBank
References
J. D. Corbin and S. H. Sharron. "Molecular Biology and Pharmacology of PDE-5-Inhibitor Therapy for Erectile Dysfunction". J. Androl. 24: S38-S41.