Opioid analgesic: Difference between revisions
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imported>Robert Badgett m (Opiod analgesic moved to Opioid analgesic: Oops) |
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''' | '''Opioid analgesics''', also called '''narcotics''', are [[drug]]s usually used for treating [[pain]]. Opiod analgesics are defined as "all of the natural and semisynthetic alkaloid derivatives from opium, their pharmacologically similar synthetic surrogates, as well as all other compounds whose opioid-like actions are blocked by the nonselective opioid receptor antagonist [[naloxone]].<ref name="isbn0-07-145153-6">{{cite book |author=Katzung, Bertram G. |title=Basic and clinical pharmacology |publisher=McGraw-Hill Medical Publishing Division |location=New York |year=2006 |pages=512 |isbn=0-07-145153-6 |oclc= |doi=}}</ref> | ||
==Pharmacology== | ==Pharmacology== | ||
There a several [[cell surface receptor]]s for opiods. All are are G-protein-coupled receptors. The major subtypes of | There a several [[cell surface receptor]]s for opiods. All are are G-protein-coupled receptors. The major subtypes of opioid receptors are: | ||
* Mu receptors are responsible for analgesia. | * Mu receptors are responsible for analgesia. | ||
* Delta | * Delta | ||
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==Available opiod analgesics== | ==Available opiod analgesics== | ||
Current | Current opioid analgesics are:<ref>{{MeSH|Opioid analgesics}}</ref> | ||
<div style="-moz-column-count:3; column-count:3;"> | <div style="-moz-column-count:3; column-count:3;"> | ||
# 18,19-dihydroetorphine | # 18,19-dihydroetorphine | ||
Revision as of 08:30, 29 May 2008
Opioid analgesics, also called narcotics, are drugs usually used for treating pain. Opiod analgesics are defined as "all of the natural and semisynthetic alkaloid derivatives from opium, their pharmacologically similar synthetic surrogates, as well as all other compounds whose opioid-like actions are blocked by the nonselective opioid receptor antagonist naloxone.[1]
Pharmacology
There a several cell surface receptors for opiods. All are are G-protein-coupled receptors. The major subtypes of opioid receptors are:
- Mu receptors are responsible for analgesia.
- Delta
- Kappa
Available opiod analgesics
Current opioid analgesics are:[2]
- 18,19-dihydroetorphine
- Alfentanil
- Alphaprodine
- beta-casomorphins
- Buprenorphine
- Butorphanol
- carfentanil
- Codeine
- deltorphin I, Ala(2)-
- dermorphin
- Dextromoramide
- Dextropropoxyphene
- dezocine
- dihydrocodeine
- Dihydromorphine
- Diphenoxylate
- dynorphin (1-13)
- endomorphin 1
- endomorphin 2
- Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
- Enkephalin, D-Penicillamine (2,5)-
- enkephalin-Met, Ala(2)-
- eseroline
- Ethylketocyclazocine
- Ethylmorphine
- Etorphine
- Fentanyl
- Heroin
- Hydrocodone
- Hydromorphone
- ketobemidone
- Levorphanol
- lofentanil
- Meperidine
- Meptazinol
- Methadone
- Methadyl Acetate
- Morphine
- Nalbuphine
- nocistatin
- Opiate Alkaloids
- Opium
- Oxycodone
- Oxymorphone
- paracymethadol
- Pentazocine
- Phenazocine
- Phenoperidine
- Pirinitramide
- Promedol
- protopine
- remifentanil
- Sufentanil
- Tilidine
- Tramadol
- tyrosyl-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-phenylalanyl-phenylalanine
References
- ↑ Katzung, Bertram G. (2006). Basic and clinical pharmacology. New York: McGraw-Hill Medical Publishing Division, 512. ISBN 0-07-145153-6.
- ↑ Anonymous (2024), Opioid analgesics (English). Medical Subject Headings. U.S. National Library of Medicine.