Liver function test: Difference between revisions
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In clinical [[medicine]], '''liver function tests''' include | In clinical [[medicine]], '''liver function tests''' include tests for:<ref name=Covin>{{citation | ||
| title = Liver and Gallbladder Pathology | |||
| author = Covin, RB | |||
| publisher = University of Medicine and Dentistry of New Jersey | |||
| date = April 4, 2006 | |||
| url = http://www2.umdnj.edu/pathpweb/Lectures/Liver%20and%20GB%20Pathology%20-%20Covin%202006.pdf}}</ref> | |||
*Surrogates for hepatic cell breakdown | |||
**Transaminases | |||
***[[alanine transaminase]]<ref>{{MeSH|Alanine transaminase}}</ref> (ALT)formerly called glutamic-pyruvic transaminase (SGPT) | |||
***[[aspartate aminotransferase]] (AST)<ref>{{MeSH|Aspartate aminotransferase}}</ref>, formerly called glutamic-oxaloacetic transaminase (SGOT) | |||
**Lactic dehydrogenase]] | |||
*Indicators of obstruction | |||
**[[Alkaline phosphatase | |||
**5’-NT (5-nucleotidase) | |||
**GGT ([[gamma-glutamyltransferase]]) | |||
**[[Bilirubin]] | |||
*Hepatic synthetic function | |||
**Protein | |||
***[[Albumin]] | |||
***[[Globulin]] | |||
***[[Albumin-globulin ratio]] | |||
*[[Coagulation factors]] | |||
**[[Prothrombin]] | |||
**[[International normalized ratio]] | |||
*Tumor markers | |||
**[[alpha-fetoprotein]] | |||
*Special | |||
**Copper metabolism | |||
***[[Ceruloplasmin]] | |||
**Iron metabolism | |||
***serum Iron | |||
***[[total iron binding capacity]] (TIBC) % transferrinsaturation | |||
***[[ferritin]] | |||
*Serology | |||
**HBsAg | |||
**Anti-HBsAg | |||
**Anti-HBcAg ([[Immunoglobin#immunoglobin G|immunoglobin G (IgG)]]) | |||
**Anti-HBcAg ([[Immunoglobin#immunoglobin M|immunoglobin M (IgM)]]) | |||
==Causes of elevated test results== | ==Causes of elevated test results== | ||
Increased blood levels of alanine transaminase have been associated with eating fast food twice a day while limiting [[exercise]].<ref name="pmid18276725">{{cite journal |author=Kechagias S, Ernersson A, Dahlqvist O, Lundberg P, Lindström T, Nystrom FH |title=Fast food based hyper-alimentation can induce rapid and profound elevation of serum alanine aminotransferase in healthy subjects |journal=Gut |volume= |issue= |pages= |year=2008 |pmid=18276725 |doi=10.1136/gut.2007.131797}}</ref> The intervention in the trial aimed to "double the regular caloric intake in combination with adoption of a sedentary lifestyle for four weeks."<ref name="pmid18276725"/> | Increased blood levels of alanine transaminase have been associated with eating fast food twice a day while limiting [[exercise]].<ref name="pmid18276725">{{cite journal |author=Kechagias S, Ernersson A, Dahlqvist O, Lundberg P, Lindström T, Nystrom FH |title=Fast food based hyper-alimentation can induce rapid and profound elevation of serum alanine aminotransferase in healthy subjects |journal=Gut |volume= |issue= |pages= |year=2008 |pmid=18276725 |doi=10.1136/gut.2007.131797}}</ref> The intervention in the trial aimed to "double the regular caloric intake in combination with adoption of a sedentary lifestyle for four weeks."<ref name="pmid18276725"/> | ||
==References== | ==References== | ||
{{reflist|2}} | |||
Revision as of 11:16, 10 November 2008
In clinical medicine, liver function tests include tests for:[1]
- Surrogates for hepatic cell breakdown
- Transaminases
- alanine transaminase[2] (ALT)formerly called glutamic-pyruvic transaminase (SGPT)
- aspartate aminotransferase (AST)[3], formerly called glutamic-oxaloacetic transaminase (SGOT)
- Lactic dehydrogenase]]
- Transaminases
- Indicators of obstruction
- [[Alkaline phosphatase
- 5’-NT (5-nucleotidase)
- GGT (gamma-glutamyltransferase)
- Bilirubin
- Hepatic synthetic function
- Protein
- Coagulation factors
- Tumor markers
- Special
- Copper metabolism
- Iron metabolism
- serum Iron
- total iron binding capacity (TIBC) % transferrinsaturation
- ferritin
- Serology
- HBsAg
- Anti-HBsAg
- Anti-HBcAg (immunoglobin G (IgG))
- Anti-HBcAg (immunoglobin M (IgM))
Causes of elevated test results
Increased blood levels of alanine transaminase have been associated with eating fast food twice a day while limiting exercise.[4] The intervention in the trial aimed to "double the regular caloric intake in combination with adoption of a sedentary lifestyle for four weeks."[4]
References
- ↑ Covin, RB (April 4, 2006), Liver and Gallbladder Pathology, University of Medicine and Dentistry of New Jersey
- ↑ Anonymous (2024), Alanine transaminase (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Anonymous (2024), Aspartate aminotransferase (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ 4.0 4.1 Kechagias S, Ernersson A, Dahlqvist O, Lundberg P, Lindström T, Nystrom FH (2008). "Fast food based hyper-alimentation can induce rapid and profound elevation of serum alanine aminotransferase in healthy subjects". Gut. DOI:10.1136/gut.2007.131797. PMID 18276725. Research Blogging.