Azlocillin: Difference between revisions
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[[Image:Azlocillin structure.jpg|right|thumb|300px|{{#ifexist:Template:Azlocillin structure.jpg/credit|{{Azlocillin structure.jpg/credit}}<br/>|}}Azlocillin, an ampicillin-like, penicillin antibiotic.]] | [[Image:Azlocillin structure.jpg|right|thumb|300px|{{#ifexist:Template:Azlocillin structure.jpg/credit|{{Azlocillin structure.jpg/credit}}<br/>|}}Azlocillin, an ampicillin-like, penicillin antibiotic.]] | ||
'''Azlocillin''' is an [[antibiotic]], <math>\beta</math> drug used to treat infections. It is an acylated form of [[ampicillin]] and is similar to the antibiotics [[mezlocillin]] and [[piperacillin]]. It has greater antibacterial activity relative to similar carboxy forms of penicillin. It is active against a wide variety of bacteria. | '''Azlocillin''' is an [[antibiotic]], <math>\beta</math>-lactam drug used to treat infections. It is an acylated form of [[ampicillin]] and is similar to the antibiotics [[mezlocillin]] and [[piperacillin]]. It has greater antibacterial activity relative to similar carboxy forms of penicillin. It is active against a wide variety of bacteria. | ||
== Mechanism of action == | |||
Amoxicillin binds to the penicillin-binding protein 1A (PBP-1A) located inside the bacterial cell well. | |||
It inhibits the last stage of bacterial cell wall synthesis by acylating the penicillin-sensitive [[transpeptidase]] C-terminal domain thereby stopping the cross-linking of [[peptidoglycan]] strands. | |||
[[Autolytic]] enzymes in the bacteria then [[lyse]] the cells. | |||
== Chemistry == | == Chemistry == | ||
Revision as of 11:37, 9 February 2008
Azlocillin is an antibiotic, -lactam drug used to treat infections. It is an acylated form of ampicillin and is similar to the antibiotics mezlocillin and piperacillin. It has greater antibacterial activity relative to similar carboxy forms of penicillin. It is active against a wide variety of bacteria.
Mechanism of action
Amoxicillin binds to the penicillin-binding protein 1A (PBP-1A) located inside the bacterial cell well. It inhibits the last stage of bacterial cell wall synthesis by acylating the penicillin-sensitive transpeptidase C-terminal domain thereby stopping the cross-linking of peptidoglycan strands. Autolytic enzymes in the bacteria then lyse the cells.
Chemistry
Azlocillin is a -lactam drug and is thus susceptible to degration by -lactamase. Its chemical name is (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[[2-[(2-oxoimidazolidine-1-carbonyl)amino]-2-phenylacetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid and it has chemical formula C20H23N5O6S.
External links
- Azlocillin - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Drug Bank [1]