Azlocillin

(CC) Image: David E. Volk
Azlocillin, an ampicillin-like, penicillin antibiotic.

Azlocillin is an antibiotic, $\beta$-lactam drug used to treat infections. It is an acylated form of ampicillin and is similar to the antibiotics mezlocillin and piperacillin. It has greater antibacterial activity relative to similar carboxy forms of penicillin. It is active against a wide variety of bacteria.

Mechanism of action

Amoxicillin binds to the penicillin-binding protein 1A (PBP-1A) located inside the bacterial cell well. It inhibits the last stage of bacterial cell wall synthesis by acylating the penicillin-sensitive transpeptidase C-terminal domain thereby stopping the cross-linking of peptidoglycan strands. Autolytic enzymes in the bacteria then lyse the cells.

Chemistry

Azlocillin is a $\beta$-lactam drug and is thus susceptible to degration by $\beta$-lactamase. Its chemical name is (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[[2-[(2-oxoimidazolidine-1-carbonyl)amino]-2-phenylacetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid and it has chemical formula C₂₀H₂₃N₅O₆S.

External links

• The most up-to-date information about Azlocillin and other drugs can be found at the following sites.
• Azlocillin - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
• Azlocillin - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
• Azlocillin - Detailed information from DrugBank.